Figure 2
From: Distinct functions of BRCA1 and BRCA2 in double-strand break repair
Distinct complexes formed by BRCA1 and BRCA2 are involved in a variety of cellular processes such as damage signalling, protein degradation and both direct and indirect effects on the mechanisms of homologous recombination and DNA repair. Defects in these processes can lead to inefficient repair of DNA damage, genomic instability and tumourigenesis.