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Figure 1 | Breast Cancer Research

Figure 1

From: Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation

Figure 1

Ubiquitin conjugating enzyme variant ( UEV ) 1A is overexpressed in breast cancer cell lines and tumor samples. (A) Amino acid sequence alignment of ubiquitin conjugating enzyme variant (Uev)1A, Uev1B, Uev1C and Mms2. Residues critical for the interaction with Ubc13 [9] are indicated with a red box. (B) Uev1 variant protein levels in human breast cancer cell lines. Whole cell extracts were analyzed by western blotting with the anti-Uev1 monoclonal antibody LN2B [39]. (C) Relative transcript levels of UEV1 variants in human breast cancer cell lines as determined by qRT-PCR. (D) Relative UEV1A transcript levels in human breast cancer cell lines as determined by qRT-PCR. (E) Relative UEV1C transcript levels in human breast cancer cell lines as determined by qRT-PCR.

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Breast Cancer Research

ISSN: 1465-542X

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