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Figure 2 | Breast Cancer Research

Figure 2

From: Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo

Figure 2

Histopathological characteristics and fraction of unique and shared mutations between cancer stem cells and bulk tumors. No association of the fraction of unique or shared mutations with any histopathological characteristics were found. Subtype classification according to immunohistochemical staining: TN (ER-, PR-, HER2-), ER pos (ER+, PR+/-, HER2-), HER2 pos (ER-, PR-, HER2+). SN: Sentinel node metastasis positive or negative. Size in mm. Proliferation according to percentage of Ki67/MIB1 positive cells. Grade according to the pathology assessment. D, Ductal; L, Lobular type. Red, beige and blue numbers indicate the fraction of mutations unique to the cancer stem cells, shared and unique to the bulk tumor, respectively. Numbers next to and in the bars of the rightmost part of the plot indicate the number of mutations in each category. ER, estrogen receptor; HER2, human epithelial growth factor receptor 2; PR, progesterone receptor; TN, triple negative.

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