Table 1 CMTC and clinicopathological variables in the internal and external validation cohorts
Variables | Internal validation cohort (n = 284) | External validation cohort (n = 2,181) | ||||||
|---|---|---|---|---|---|---|---|---|
CMTC-1 number (%) | CMTC-2 number (%) | CMTC-3 number (%) | Pvalue | CMTC-1 number (%) | CMTC-2 number (%) | CMTC-3 number (%) | P value | |
Total | 92(32.4) | 106(37.3) | 86(30.3) | 805(36.9) | 603(27.6) | 773(35.4) | ||
Age | ||||||||
<50 | 24(26.1) | 34(32.1) | 21(24.4) | 4.52E-01 | 156(19.4) | 92(15.3) | 242(31.3) | 4.03E-13 |
> = 50 | 68(73.9) | 72(67.9) | 65(75.6) | 649(80.6) | 511(84.7) | 531(68.7) | ||
Size | ||||||||
<=2 cm | 56(60.9) | 47(44.3) | 40(46.5) | 4.71E-02 | 412(51.6) | 221(37.1) | 294(38.7) | 6.01E-09 |
>2 cm | 36(39.1) | 59(55.7) | 46(53.5) | 387(48.4) | 374(62.9) | 465(61.3) | ||
LN | ||||||||
(-) | 59(64.1) | 68(64.2) | 56(65.1) | 9.88E-01 | 499(62.1) | 298(49.5) | 358(46.6) | 6.49E-10 |
(+) | 33(35.9) | 38(35.8) | 30(34.9) | 305(37.9) | 304(50.5) | 411(53.4) | ||
Grade | ||||||||
1 | 20(21.7) | 5(4.7) | 2(2.3) | 8.34E-17 | 161(21.4) | 30(5.2) | 16(2.2) | 1.36E-125 |
2 | 59(64.1) | 37(34.9) | 18(20.9) | 454(60.3) | 253(43.8) | 143(19.4) | ||
3 | 13(14.1) | 64(60.4) | 66(76.7) | 138(18.3) | 294(51.0) | 580(78.5) | ||
ER | ||||||||
(-) | 1(1.1) | 0(0.0) | 57(66.3) | 2.20E-35 | 34(4.2) | 17(2.8) | 554(71.7) | 4.26E-251 |
(+) | 91(98.9) | 106(100.0) | 29(33.7) | 771(95.8) | 586(97.2) | 219(28.3) | ||
HER2+/TN | ||||||||
No | 90(97.8) | 89(84.0) | 17(19.8) | 4.63E-32 | 776(96.4) | 542(89.9) | 180(23.3) | 2.58E-251 |
Yes | 2(2.2) | 17(16.0) | 69(80.2) | 29(3.6) | 61(10.1) | 593(76.7) | ||
Eventa | ||||||||
No | 91(98.9) | 100(94.3) | 75(87.2) | 5.54E-03 | 686(85.2) | 415(68.8) | 494(63.9) | 3.15E-22 |
Yes | 1(1.1) | 6(5.7) | 11(12.8) | 119(14.8) | 188(31.2) | 279(36.1) | ||