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Table 3 Relationship between Ki67 and phosphatidylinositol 3-kinase pathway gene signatures a

From: Relationship of PIK3CA mutation and pathway activity with antiproliferative response to aromatase inhibition

   With PAGs Without PAGs
   PIK3CA-GS (Loi) PI3K-GS (Creighton) PTEN-loss-GS (Saal) PIK3CA-noPAG-GS (Loi) PI3K-noPAG-GS (Creighton) PTEN-loss-noPAG-GS (Saal)
  n Spearman’s r P-value Spearman’s r P-value Spearman’s r P-value Spearman’s r P-value Spearman’s r P-value Spearman’s r P-value
Baseline Ki67 64 -0.101 0.427 0.371 0.003 0.508 <0.0001 -0.082 0.518 0.370 0.003 0.347 0.005
2-week Ki67 57 0.084 0.534 0.188 0.162 0.219 0.102 0.120 0.374 0.186 0.167 0.132 0.329
2-wk/pre-Ki67% 56 0.212 0.117 0.036 0.792 -0.004 0.976 0.246 0.068 0.033 0.811 -0.017 0.901
  1. aGS, Gene signature; PAG, Proliferation-associated gene.