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Figure 5 | Breast Cancer Research

Figure 5

From: Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells

Figure 5

Caspase 3/7 activity and cell cycle distribution of 92 J isogenic cell lines upon lestaurtinib and/or AG14361 treatment. (A, B) Percentage of caspase 3/7 activity in 92 J isogenic pair of cells after they were incubated with IC50 of lestaurtinib and/or AG14361 in a time-dependent manner. (C, D) Distribution of 92 J isogenic pair of cells after they were treated with IC50 of AG14361 and/or lestaurtinib per 12, 24, 36 and 48 hr. There was no difference in the results between the two isogenic cell lines. IC50, 50% inhibition dose.

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Breast Cancer Research

ISSN: 1465-542X

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