Table 2 New proposal for surrogate definitions of intrinsic subtypes of HER2-negative, endocrine-responsive breast cancer a
Intrinsic subtypes | Clinicopathological surrogate definitions |
|---|---|
Luminal A | “Luminal A–like” |
All of: | |
ER-positive | |
HER2-negative | |
And at least one of: | |
Ki-67 low expression (<14%) | |
Ki-67 intermediate expression (14% to 19%) and PgR high expression (≥20%) | |
Luminal B (HER2-negative) | “Luminal B–like (HER2-negative)” |
All of: | |
ER-positive | |
HER2-negative | |
And at least one of: | |
Ki-67 intermediate expression (14% to -19) and PgR negative or low expression (<20%) | |
Ki-67 high expression (≥20%) |