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Table 2 New proposal for surrogate definitions of intrinsic subtypes of HER2-negative, endocrine-responsive breast cancer a

From: Proposed new clinicopathological surrogate definitions of luminal A and luminal B (HER2-negative) intrinsic breast cancer subtypes

Intrinsic subtypes Clinicopathological surrogate definitions
Luminal A “Luminal A–like”
All of:
ER-positive
HER2-negative
And at least one of:
Ki-67 low expression (<14%)
Ki-67 intermediate expression (14% to 19%) and PgR high expression (≥20%)
Luminal B (HER2-negative) “Luminal B–like (HER2-negative)”
  All of:
ER-positive
HER2-negative
And at least one of:
Ki-67 intermediate expression (14% to -19) and PgR negative or low expression (<20%)
Ki-67 high expression (≥20%)
  1. aER, Estrogen receptor; HER2, Human epidermal growth factor receptor 2; PgR, Progesterone receptor.