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Table 1 Characteristics of the patients a

From: Proposed new clinicopathological surrogate definitions of luminal A and luminal B (HER2-negative) intrinsic breast cancer subtypes

Variables

Number of patients (%)

All

9,415 (100)

Age at surgery, yr

 

 <35

309 (3.3)

 35 to 50

3,809 (40.5)

 51 to 65

3,637 (38.6)

 >65

1,660 (17.6)

Menopausal status

 

 Premenopausal

4,278 (45.4)

 Postmenopausal

5,137 (54.6)

Histological tumor subtype

 

 Ductal

7,114 (75.6)

 Lobular

1,150 (12.2)

 Mixed

397 (4.2)

 Other

754 (8.0)

pT

 

 pT1

6,601 (70.1)

 pT2

2,514 (26.7)

 pT3/4

300 (3.2)

pN

 

 pNx

309 (3.3)

 pN0

5,201 (55.2)

 pN+

3,905 (41.5)

Tumor grade

 

 G1

2,160 (22.9)

 G2

4,930 (52.4)

 G3

2,007 (21.3)

 NA

318 (3.4)

ER positivity

 

 ≥20%

9,228 (98.0)

 <20%

187 (2.0)

PgR positivity

 

 ≥20%

6,758 (71.8)

 <20%

2,657 (28.2)

Ki-67 level

 

 <14%

3,169 (33.7)

 14% to 19%

2,276 (24.2)

 ≥20%

3,970 (42.2)

PVI

 

 Absent

7,039 (74.8)

 Present

2,376 (25.2)

Surgery

 

 Quadrantectomy

7,777 (82.6)

 Mastectomy

1,638 (17.4)

Radiotherapy

 

 No

1,416 (15.0)

 Yes

7,999 (85.0)

Chemotherapy

 

 No

6,386 (67.8)

 Yes

3,029 (32.2)

Competing riskb

 

 No events

7,149 (75.9)

 Locoregional relapse

592 (6.3)

 Distant metastasis

852 (9.0)

 Other

822 (8.7)

  1. aER, Estrogen receptor; NA, Not applicable; PgR, Progesterone receptor; pN, Pathologic node stage; pT, Pathologic tumor stage; PVI, Peritumoral vascular invasion. bDuring a median follow-up time, estimated in nonevents, of 8.1 years (IQR = 6.1 to 10.2 years).