Variable
|
Case (n = 411), n (%)
|
Control (n = 1,212), n (%)
|
OR (95% CI)
|
Pvalue
|
Adjusted OR (95% CI)*
|
Pvalue
|
Adjusted OR (95% CI)‡
|
Pvalue
|
---|
Genetic risk score, quartiles (range), mean
| | | | | | | | |
First (32.4-43.6), 40.4
|
80 (19.5)
|
326 (26.9)
|
1.00 (ref)
| |
1.00 (ref)
| |
1.00 (ref)
| |
Second (43.6-47.1), 45.4
|
96 (23.4)
|
310 (25.6)
|
1.26 (0.90, 1.75)
|
0.178
|
1.25 (0.90, 1.75)
|
0.182
|
1.26 (0.90, 1.76)
|
0.174
|
Third (47.1-50.6), 48.9
|
109 (26.5)
|
296 (24.4)
|
1,47 (1.06, 2.04)
|
0.020
|
1.49 (1.07, 2.06)
|
0.017
|
1.47 (1.06, 2.04)
|
0.022
|
Fourth (50.6-65.8), 53.6
|
126 (30.7)
|
280 (23.1)
|
1.78 (1.29, 2.44)
|
<0.001
|
1.74 (1.26, 2.40)
|
0.001
|
1.75 (1.27, 2.41)
|
0.001
|
P trend
| | |
1.21 (1.09, 1.33)
|
<0.001
|
1.20 (1.09, 1.33)
|
<0.001
|
1.20 (1.08, 1.33)
|
<0.001
|
Age at first live birth, years
| | | | | | | | |
<20
|
56 (13.6)
|
212 (17.5)
|
1.00 (ref)
| |
1.00 (ref)
| |
1.00 (ref)
| |
20-24
|
129 (31.4)
|
458 (37.8)
|
1.11 (0.77, 1.59)
|
0.571
|
1.04 (0.72, 1.50)
|
0.823
|
1.05 (0.73, 1.51)
|
0.804
|
25-29 or null
|
175 (42.6)
|
416 (34.3)
|
1.67 (1.16, 2.39)
|
0.005
|
1.51 (1.04, 2.18)
|
0.030
|
1.49 (1.03, 2.15)
|
0.036
|
≥30
|
51 (12.4)
|
126 (10.4)
|
1.62 (1.03, 2.55)
|
0.038
|
1.46 (0.92, 2.31)
|
0.111
|
1.49 (1.03, 2.29)
|
0.131
|
P trend
| | |
1.25 (1.09, 1.42)
|
0.001
|
1.20 (1.05, 1.38)
|
0.008
|
1.19 (1.04, 1.37)
|
0.011
|
Age at menarche, years
| | | | | | | | |
≥14
|
160 (38.9)
|
540 (44.6)
|
1.00 (ref)
| |
1.00 (ref)
| |
1.00 (ref)
| |
12-13
|
180 (43.8)
|
484 (39.9)
|
1.29 (1.00, 1.66)
|
0.049
|
1.21 (0.93, 1.56)
|
0.151
|
1.23 (0.94, 1.60)
|
0.126
|
<12
|
71 (17.3)
|
188 (15.5)
|
1.34 (0.95, 1.89)
|
0.097
|
1.20 (0.84, 1.71)
|
0.312
|
1.19 (0.83, 1.71)
|
0.345
|
P trend
| | |
1.18 (1.00, 1.39)
|
0.048
|
1.12 (0.94, 1.32)
|
0.208
|
1.11 (0.94, 1.33)
|
0.220
|
Family history
| | | | | | | | |
No
|
400 (97.3)
|
1196 (98.7)
|
1.00 (ref)
| |
1.00 (ref)
| |
1.00 (ref)
| |
Yes
|
11 (2.7)
|
16 (1.3)
|
2.11 (0.97, 4.61)
|
0.061
|
2.06 (0.94, 4.52)
|
0.071
|
1.78 (0.79, 4.00)
|
0.162
|
Past breast biopsy, n (%)
| | | | | | | | |
No
|
401 (97.6)
|
1193 (98.4)
|
1.00 (ref)
| |
1.00 (ref)
| |
1.00 (ref)
| |
Yes
|
10 (2.4)
|
19 (1.6)
|
1.55 (0.69, 3.48)
|
0.288
|
1.36 (0.60, 3.08)
|
0.462
|
1.36 (0.58, 3.20)
|
0.475
|
Body mass index, kg/m2
| | | | | | | | |
<20
|
51 (12.4)
|
167 (13.8)
|
1.00 (ref)
| |
1.00 (ref)
| |
1.00 (ref)
| |
20 to <24
|
216 (52.6)
|
659 (54.4)
|
1.09 (0.77, 1.54)
|
0.632
|
1.11 (0.78, 1.58)
|
0.562
|
1.16 (0.81, 1.66)
|
0.423
|
24 to <28
|
102 (24.8)
|
305 (25.2)
|
1.10 (0.75, 1.62)
|
0.610
|
1.12 (0.76, 1.64)
|
0.558
|
1.15 (0.78, 1.70)
|
0.488
|
28 or higher
|
42 (10.2)
|
81 (6.7)
|
1.74 (1.07, 2.85)
|
0.027
|
1.83 (1.12, 3.01)
|
0.016
|
1.99 (1.21, 3.29)
|
0.007
|
P trend
| | |
1.14 (0.99, 1.31)
|
0.067
|
1.15 (1.00, 1.33)
|
0.048
|
1.17 (1.02, 1.35)
|
0.031
|
- ‡Adjusted for education; ‡adjusted for education and all other factors in the table. OR, odds ratio; CI, confidence interval.