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Table 3 The relation for genetic risk score and established conventional risk factors with risk of breast cancer, The Singapore Chinese Health Study, 1993 to 1998

From: Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population

Variable Case (n = 411), n (%) Control (n = 1,212), n (%) OR (95% CI) Pvalue Adjusted OR (95% CI)* Pvalue Adjusted OR (95% CI)‡ Pvalue
Genetic risk score, quartiles (range), mean         
First (32.4-43.6), 40.4 80 (19.5) 326 (26.9) 1.00 (ref)   1.00 (ref)   1.00 (ref)  
Second (43.6-47.1), 45.4 96 (23.4) 310 (25.6) 1.26 (0.90, 1.75) 0.178 1.25 (0.90, 1.75) 0.182 1.26 (0.90, 1.76) 0.174
Third (47.1-50.6), 48.9 109 (26.5) 296 (24.4) 1,47 (1.06, 2.04) 0.020 1.49 (1.07, 2.06) 0.017 1.47 (1.06, 2.04) 0.022
Fourth (50.6-65.8), 53.6 126 (30.7) 280 (23.1) 1.78 (1.29, 2.44) <0.001 1.74 (1.26, 2.40) 0.001 1.75 (1.27, 2.41) 0.001
P trend    1.21 (1.09, 1.33) <0.001 1.20 (1.09, 1.33) <0.001 1.20 (1.08, 1.33) <0.001
Age at first live birth, years         
<20 56 (13.6) 212 (17.5) 1.00 (ref)   1.00 (ref)   1.00 (ref)  
20-24 129 (31.4) 458 (37.8) 1.11 (0.77, 1.59) 0.571 1.04 (0.72, 1.50) 0.823 1.05 (0.73, 1.51) 0.804
25-29 or null 175 (42.6) 416 (34.3) 1.67 (1.16, 2.39) 0.005 1.51 (1.04, 2.18) 0.030 1.49 (1.03, 2.15) 0.036
≥30 51 (12.4) 126 (10.4) 1.62 (1.03, 2.55) 0.038 1.46 (0.92, 2.31) 0.111 1.49 (1.03, 2.29) 0.131
P trend    1.25 (1.09, 1.42) 0.001 1.20 (1.05, 1.38) 0.008 1.19 (1.04, 1.37) 0.011
Age at menarche, years         
≥14 160 (38.9) 540 (44.6) 1.00 (ref)   1.00 (ref)   1.00 (ref)  
12-13 180 (43.8) 484 (39.9) 1.29 (1.00, 1.66) 0.049 1.21 (0.93, 1.56) 0.151 1.23 (0.94, 1.60) 0.126
<12 71 (17.3) 188 (15.5) 1.34 (0.95, 1.89) 0.097 1.20 (0.84, 1.71) 0.312 1.19 (0.83, 1.71) 0.345
P trend    1.18 (1.00, 1.39) 0.048 1.12 (0.94, 1.32) 0.208 1.11 (0.94, 1.33) 0.220
Family history         
No 400 (97.3) 1196 (98.7) 1.00 (ref)   1.00 (ref)   1.00 (ref)  
Yes 11 (2.7) 16 (1.3) 2.11 (0.97, 4.61) 0.061 2.06 (0.94, 4.52) 0.071 1.78 (0.79, 4.00) 0.162
Past breast biopsy, n (%)         
No 401 (97.6) 1193 (98.4) 1.00 (ref)   1.00 (ref)   1.00 (ref)  
Yes 10 (2.4) 19 (1.6) 1.55 (0.69, 3.48) 0.288 1.36 (0.60, 3.08) 0.462 1.36 (0.58, 3.20) 0.475
Body mass index, kg/m2         
<20 51 (12.4) 167 (13.8) 1.00 (ref)   1.00 (ref)   1.00 (ref)  
20 to <24 216 (52.6) 659 (54.4) 1.09 (0.77, 1.54) 0.632 1.11 (0.78, 1.58) 0.562 1.16 (0.81, 1.66) 0.423
24 to <28 102 (24.8) 305 (25.2) 1.10 (0.75, 1.62) 0.610 1.12 (0.76, 1.64) 0.558 1.15 (0.78, 1.70) 0.488
28 or higher 42 (10.2) 81 (6.7) 1.74 (1.07, 2.85) 0.027 1.83 (1.12, 3.01) 0.016 1.99 (1.21, 3.29) 0.007
P trend    1.14 (0.99, 1.31) 0.067 1.15 (1.00, 1.33) 0.048 1.17 (1.02, 1.35) 0.031
  1. ‡Adjusted for education; ‡adjusted for education and all other factors in the table. OR, odds ratio; CI, confidence interval.
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Breast Cancer Research

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