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Table 3 The relation for genetic risk score and established conventional risk factors with risk of breast cancer, The Singapore Chinese Health Study, 1993 to 1998

From: Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population

Variable

Case (n = 411), n (%)

Control (n = 1,212), n (%)

OR (95% CI)

Pvalue

Adjusted OR (95% CI)*

Pvalue

Adjusted OR (95% CI)

Pvalue

Genetic risk score, quartiles (range), mean

        

First (32.4-43.6), 40.4

80 (19.5)

326 (26.9)

1.00 (ref)

 

1.00 (ref)

 

1.00 (ref)

 

Second (43.6-47.1), 45.4

96 (23.4)

310 (25.6)

1.26 (0.90, 1.75)

0.178

1.25 (0.90, 1.75)

0.182

1.26 (0.90, 1.76)

0.174

Third (47.1-50.6), 48.9

109 (26.5)

296 (24.4)

1,47 (1.06, 2.04)

0.020

1.49 (1.07, 2.06)

0.017

1.47 (1.06, 2.04)

0.022

Fourth (50.6-65.8), 53.6

126 (30.7)

280 (23.1)

1.78 (1.29, 2.44)

<0.001

1.74 (1.26, 2.40)

0.001

1.75 (1.27, 2.41)

0.001

P trend

  

1.21 (1.09, 1.33)

<0.001

1.20 (1.09, 1.33)

<0.001

1.20 (1.08, 1.33)

<0.001

Age at first live birth, years

        

<20

56 (13.6)

212 (17.5)

1.00 (ref)

 

1.00 (ref)

 

1.00 (ref)

 

20-24

129 (31.4)

458 (37.8)

1.11 (0.77, 1.59)

0.571

1.04 (0.72, 1.50)

0.823

1.05 (0.73, 1.51)

0.804

25-29 or null

175 (42.6)

416 (34.3)

1.67 (1.16, 2.39)

0.005

1.51 (1.04, 2.18)

0.030

1.49 (1.03, 2.15)

0.036

≥30

51 (12.4)

126 (10.4)

1.62 (1.03, 2.55)

0.038

1.46 (0.92, 2.31)

0.111

1.49 (1.03, 2.29)

0.131

P trend

  

1.25 (1.09, 1.42)

0.001

1.20 (1.05, 1.38)

0.008

1.19 (1.04, 1.37)

0.011

Age at menarche, years

        

≥14

160 (38.9)

540 (44.6)

1.00 (ref)

 

1.00 (ref)

 

1.00 (ref)

 

12-13

180 (43.8)

484 (39.9)

1.29 (1.00, 1.66)

0.049

1.21 (0.93, 1.56)

0.151

1.23 (0.94, 1.60)

0.126

<12

71 (17.3)

188 (15.5)

1.34 (0.95, 1.89)

0.097

1.20 (0.84, 1.71)

0.312

1.19 (0.83, 1.71)

0.345

P trend

  

1.18 (1.00, 1.39)

0.048

1.12 (0.94, 1.32)

0.208

1.11 (0.94, 1.33)

0.220

Family history

        

No

400 (97.3)

1196 (98.7)

1.00 (ref)

 

1.00 (ref)

 

1.00 (ref)

 

Yes

11 (2.7)

16 (1.3)

2.11 (0.97, 4.61)

0.061

2.06 (0.94, 4.52)

0.071

1.78 (0.79, 4.00)

0.162

Past breast biopsy, n (%)

        

No

401 (97.6)

1193 (98.4)

1.00 (ref)

 

1.00 (ref)

 

1.00 (ref)

 

Yes

10 (2.4)

19 (1.6)

1.55 (0.69, 3.48)

0.288

1.36 (0.60, 3.08)

0.462

1.36 (0.58, 3.20)

0.475

Body mass index, kg/m2

        

<20

51 (12.4)

167 (13.8)

1.00 (ref)

 

1.00 (ref)

 

1.00 (ref)

 

20 to <24

216 (52.6)

659 (54.4)

1.09 (0.77, 1.54)

0.632

1.11 (0.78, 1.58)

0.562

1.16 (0.81, 1.66)

0.423

24 to <28

102 (24.8)

305 (25.2)

1.10 (0.75, 1.62)

0.610

1.12 (0.76, 1.64)

0.558

1.15 (0.78, 1.70)

0.488

28 or higher

42 (10.2)

81 (6.7)

1.74 (1.07, 2.85)

0.027

1.83 (1.12, 3.01)

0.016

1.99 (1.21, 3.29)

0.007

P trend

  

1.14 (0.99, 1.31)

0.067

1.15 (1.00, 1.33)

0.048

1.17 (1.02, 1.35)

0.031

  1. Adjusted for education; adjusted for education and all other factors in the table. OR, odds ratio; CI, confidence interval.