Effect of increasing number of SNPs in breast cancer risk assessment. The rate of increase in model discriminatory power (difference in log five-year absolute risk) between cases and controls diminishes as more SNPs are incorporated into the GRS. For instance, the change in improvement of model performance is minimal when the number of SNPs used in the GRS increased from 16 to 51. GRS is obtained by pooling the ORs of local and published studies. Y-axis is the density that reflects the frequency of subjects. (Black - controls, Red - cases). SNP, single nucleotide polymorphism; GRS, genetic risk score; OR, odds ratio.