Figure 1

Receiver operating characteristic (ROC) curve analysis comparing the performance of five-protein and four-protein panels on training and validation data sets. When used to distinguish serum samples from breast cancer patients (BC) from those from the healthy volunteer (HV) group, the average ROC area under the curve (AUC) was 0.961 for the five-protein parameter in the training set (A) and 0.939 in the independent validation set (B). For the four-protein parameter, the average value of ROC-AUC was 0.935 in the training set (C) and 0.954 in the validation set (D).