Upstream regulator | Predicted activation state | Activation z-score | P-value of overlap |
---|---|---|---|
TGFβ1 | Activated | 2,580 | 4,76E-16 |
SMAD2 | Activated | 2,204 | 7,91E-06 |
SMAD3 | Activated | 2,138 | 8,05E-06 |
NOTCH1 | Activated | 2,102 | 3,87E-05 |
Tgf β | Activated | 2,241 | 5,70E-05 |
MKL1 | Activated | 2,744 | 4,28E-04 |
MKL2 | Activated | 2,449 | 2,49E-03 |
MGEA5 | Activated | 2,887 | 6,60E-03 |
INSIG1 | Activated | 2,621 | 9,33E-03 |
GFI1 | Activated | 2,236 | 1,56E-02 |
TNF | Inhibited | −2,756 | 1,52E-15 |
IL1B | Inhibited | −2,446 | 2,96E-09 |
TP53 | Inhibited | −2,871 | 5,83E-08 |
NFkβ (complex) | Inhibited | −2,030 | 1,20E-07 |
CEBPA | Inhibited | −2,457 | 1,66E-06 |
TP63 | Inhibited | −2,301 | 5,32E-06 |
RELA | Inhibited | −2,192 | 5,25E-05 |
PDGF BB | Inhibited | −2,883 | 2,02E-04 |
MYCN | Inhibited | −2,440 | 9,87E-04 |
ALDH2 | Inhibited | −2,000 | 1,17E-03 |
CHUK | Inhibited | −2,101 | 1,39E-03 |
PPARG | Inhibited | −2,476 | 1,46E-03 |
TGFB3 | Â | 1,286 | 4,60E-08 |
INHBA |  | −0.341 | 7.33E-05 |
TGFβR2 |  | −0,296 | 1,59E-04 |
SMAD4 | Â | 0,659 | 1,80E-04 |
BMP7 |  | −0,464 | 2,17E-04 |