Model | Arrays | Promoter | Description | References |
---|---|---|---|---|
Myc | 319 | MMTV WAP/Dox | Myc mammary tumors of various histological types, expression levelsand stability with variable Kras mutations. | |
Neu | 124 | MMTV | Induction of adenocarcinomas with pulmonary metastasis. | |
PyMT | 119 | MMTV K6/RCAS MMTV/RCAS | Rapid induction of luminal-type mammary tumors with pulmonarymetastasis. | |
SV40 Large T Antigen | 107 | C3 WAP | Induction of mammary tumors with similarities to human basal typebreast cancer. | |
p53 | 92 | Null | Tumors with similarities to human basal type breast cancer. | |
CreEtv6/NTRK3 | 63 | WAP | Fusion oncoprotein transforms through activation of AP1. | [54] |
MET | 52 | MMTV | Diverse histologies with similarities to human basal breastcancer. | [16] |
BRCA/p53 | 46 | WAP MMTV BLG | CKO of BRCA1 in a p53 null background. Tumors similar to human basalbreast cancer. | |
Wnt | 35 | MMTV | Induction of mammary tumors with diverse gene expression patterns. | |
IGF-IR | 26 | MTB | Basal-like mammary tumors. Recurrent tumors resemble humanclaudin-low. | [59] |
LPA | 16 | MMTV | ER positive, metastatic tumors. | [60] |
Stat5 | 16 | BLG | Induction of mammary tumors | NA |
Brg1 (+/−) | 14 | Mutant | Heterogeneous breast cancers. | [61] |
DMBA | 12 | Chemical | Mammary carcinomas with three phenotypes: adenocarcinoma, squamouscell carcinoma, and myoepithelial cell carcinoma. | [62] |
Ras | 10 | MMTV | Induction of mammary tumors with rapid tumor onset. | [38] |
Int3 | 9 | WAP | Metastatic tumors. | [63] |
RB/p107 | 7 | CKO | Adeno and adenosquamous carcinomas similar to luminal B or basal. | [64] |
APC CKO | 6 | K14-Cre | CKO results in adenocarcinomas with histological and molecularheterogeneity. | [65] |
Autotaxin (ATX) | 5 | MMTV | ER + metastatic mammary tumors. | [60] |
BRCA | 5 | CKO | Tumors similar to human basal type breast cancer. | NA |
STAT1 | 5 | Knockout | ERa + PR+, hormone dependent like humanERa + luminal. | [66] |
Notch | 4 | Dox | Induction of mammary adenocarcinomas. | NA |
PDK1 | 2 | MMTV | Induction of mammary tumors | [67] |
Normal Mammary Gland | 47 | Not Applicable | Normal mammary gland samples from FVB, BalbC, and CD1 geneticbackgrounds. |