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Figure 2 | Breast Cancer Research

Figure 2

From: Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers

Figure 2

Scoring by genomic scars of homologous recombination deficiency and drug response. Eight examples of various forms of structural copy number aberrations and rearrangements are given, whereby each box, lettered A to F, represents a genomic segment of approximately 3 Mbp in length. Below the chromosomes, the three genomic scars - homologous recombination defect (HRD), telomeric allelic imbalance score (NtAi), and large-scale transition (LST) - are listed along with the respective integer count for the scar (0 = not seen, 1 = detected once). LOH, loss of heterozygosity.

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