Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Frequency vs odds ratio for confirmed HRR breast cancer susceptibility genes

From: Rare key functional domain missense substitutions in MRE11A, RAD50, and NBNcontribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study

Gene Frequency bins (%) 1.000 - 0.320 OR (95% CI) 0.320 - 0.100 OR (95% CI) 0.100 - 0.032 OR (95% CI) 0.032 - 0.000 OR (95% CI)
ATM¥ 0.00¢ 0.57 (0.12-2.80) 1.13 (0.30-4.24) 2.61 (1.57-4.35)
BRCA1§ no variants no variants no variants 2.06 (1.06-4.57)
BRCA2§ no variants 0.96 (0.64-1.43) 1.60 (0.95-2.70) 1.57 (1.15-2.15)
CHEK2 0.99 (0.20-4.91) 3.40 (1.22-9.47) 1.68 (0.29-9.78) 3.31 (1.49-7.37)
  1. Boldface within the table indicates P <0.05. ¥Underlying data from [19]. Analyses were performed on data from the nine bona fide case-control studies. Missense substitutions were only included if they fell after position 1960 in the protein sequence. Odds ratios adjusted for study, ethnicity and mutation-screening method employed. ¢This grouping included just one missense substitution carried by just one control subject. §Underlying data from [33]. Underlying data from [20]; odds ratios adjusted for study center and race/ethnicity.