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Table 2 Frequency vs odds ratio for confirmed HRR breast cancer susceptibility genes

From: Rare key functional domain missense substitutions in MRE11A, RAD50, and NBNcontribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study

Gene

Frequency bins (%) 1.000 - 0.320 OR (95% CI)

0.320 - 0.100 OR (95% CI)

0.100 - 0.032 OR (95% CI)

0.032 - 0.000 OR (95% CI)

ATMÂ¥

0.00¢

0.57 (0.12-2.80)

1.13 (0.30-4.24)

2.61 (1.57-4.35)

BRCA1§

no variants

no variants

no variants

2.06 (1.06-4.57)

BRCA2§

no variants

0.96 (0.64-1.43)

1.60 (0.95-2.70)

1.57 (1.15-2.15)

CHEK2†

0.99 (0.20-4.91)

3.40 (1.22-9.47)

1.68 (0.29-9.78)

3.31 (1.49-7.37)

  1. Boldface within the table indicates P <0.05. ¥Underlying data from [19]. Analyses were performed on data from the nine bona fide case-control studies. Missense substitutions were only included if they fell after position 1960 in the protein sequence. Odds ratios adjusted for study, ethnicity and mutation-screening method employed. ¢This grouping included just one missense substitution carried by just one control subject. §Underlying data from [33]. †Underlying data from [20]; odds ratios adjusted for study center and race/ethnicity.