| | Breast cancer cohort |
---|
| | GSE6532 (Loi) | NKI | TCGA |
---|
Variable | Ref for HR = 1 | Hazard ratio | CI | Pvalue | Hazard ratio | CI | Pvalue | Hazard ratio | CI | Pvalue |
---|
TSTSS
|
High
|
1.89
|
1.1-3.27
|
0.02211
|
1.81
|
1.12-2.93
|
0.01535
|
2.6
|
1.21-5.58
|
0.0142
|
metaPCNA | Low | 2.32 | 1.27-4.24 | 0.006251 | 1.67 | 0.96-2.92 | 0.07143 | 0.77 | 0.38-1.58 | 0.4788 |
Age | Low* | 1.03 | 0.63-1.69 | 0.9 | 0.52 | 0.32-0.84 | 0.007841 | 1.88 | 0.94-3.75 | 0.07393 |
Node | Negative | 0.91 | 0.54-1.53 | 0.7113 | 0.84 | 0.52-1.34 | 0.4651 | 2.33 | 1.07-5.08 | 0.03389 |
Grade | Grade 1 | 0.99 | 0.67-1.47 | 0.9798 | 1.57 | 1.1-2.25 | 0.01365 | na | na | na |
Size | Continuous | 1.33 | 1.09-1.62 | 0.005177 | 1.22 | 0.95-1.57 | 0.1109 | na | na | na |
- Multivariate analysis was performed using the Cox proportional hazards model. Nineteen out of the 26 genes of the TSTSS were found in the GSE6532 (Loi) and NKI cohorts, and 24 out of 26 genes were found in the TCGA cohort. The TSTSS was analyzed as a binary variable where high indicates higher than median expression. The hazard ratio refers to distant metastasis-free survival for GSE6532 and NKI, and overall survival for TCGA. The metaPCNA index is a surrogate for proliferation and low indicates lower than median expression. Parameters for the TSTSS are highlighted in bold. *Low is ≤61 yrs (GSE6532); ≤45 yrs (NKI); ≤60 yrs (TCGA). HR, hazard ratio; CI, confidence interval; TSTSS, TGF-β/Smad3 tumor suppressor signature; na, not available.