Figure 3From: Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumorsDifferential p53 pathway activation in organotypic breast tumors. (A) Immunohistochemical analysis of differential expression of p53, p21Waf1 or MDM2 in control (Ctrl)- or doxorubicin (Doxo)-treated breast tumors after 48 h. Tissue morphology and proliferative index were determined by hematoxylin and eosin (H&E) and Ki-67 staining of the same cases, respectively. A representative case for Non Responder (left) or Responder (right) breast tumors ex vivo is shown. Original magnification, x200. (B-D) Quantification of p53 (B), p21Waf1 (C) or MDM2 (D) proteins levels in Ctrl or Doxo-treated Responder versus Non Responder breast tumors at the indicated time intervals. #P = 0.03 *P = 0.01; **P = 0.007 (unpaired t test).Back to article page