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Figure 6 | Breast Cancer Research

Figure 6

From: C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment

Figure 6

CXCR7 expression in human breast tumors correlates with worse patient outcome and CXCR7 and STAT3 expression in breast cancer patients. (A) Overall survival (OS) of TCGA IDC patients with or without ackr3 overexpression (greater than 1.0-fold SD above mean). (B) Lung metastasis-free survival (LMFS) of IDC patients from study GSE2603. LMFS was compared between 20 high-CXCR7- and 20 low-CXCR7-expressing patients. (C) Breast tumors and adjacent normal tissue (n = 4) were lysed with RIPA buffer, and the lysates were analyzed with Western blotting by using specific antibodies against p-STAT3 (86 kDa), CXCR7 (52 kDa), and GAPDH (37 kDa) as loading control. (D, E) Representative tissue microarray cores of normal and cancerous breast tissue (20×, scale bar, 0.03 mm). Tissue microarray (TMA) samples containing 10 normal, 10 metastatic, and 38 invasive ductal carcinomas (IDCs) were analyzed with immunohistochemistry by using CXCR7 antibodies (kindly provided by ChemoCentryx).

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