Skip to main content

Table 1 Association of rs10235235 with risk of breast cancer for women of European ancestry: stratified analysis

From: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

  Cases Controls ORhet 95% CI P 1 ORhom 95% CI P 1 P het
ER status          
 ER-positive 24,780 38,739 0.99 0.95, 1.03 0.61 0.83 0.70, 0.99 0.04  
 ER-negative 5,851 38,739 1.02 0.95, 1.10 0.60 0.60 0.43, 0.86 0.005  
 NK 8,339         
 Total 38,970a 38,739 0.99 0.95, 1.03 0.74 0.79 0.67, 0.94 0.006 0.83
PR status          
 PR-positive 18,497 39,033 0.98 0.93, 1.02 0.32 0.82 0.67, 0.99 0.04  
 PR-negative 8,193 39,033 1.02 0.96, 1.09 0.53 0.74 0.56, 0.98 0.03  
 NK 12,111         
 Total 38,801b 39,033 0.99 0.94, 1.03 0.52 0.80 0.67, 0.95 0.01 0.19
Morphology          
 Ductal 22,123 31,803 0.98 0.93, 1.02 0.30 0.74 0.61, 0.90 0.003  
 Lobular 3,921 31,803 1.07 0.98, 1.17 0.14 0.91 0.64, 1.27 0.57  
 Other and NK 5,995         
 Total 32,039 31,803 0.99 0.95, 1.04 0.64 0.77 0.64, 0.92 0.004 0.03
Grade          
 Grade 1 5,944 37,285 0.97 0.90, 1.05 0.46 0.86 0.65, 1.15 0.31  
 Grade 2 13,427 37,285 1.00 0.95, 1.06 0.92 0.80 0.63, 0.98 0.04  
 Grade 3 8,638 37,285 0.98 0.92, 1.05 0.58 0.61 0.46, 0.82 0.001  
 NK 8,769         
 Total 36,778 37,285 0.99 0.95, 1.03 0.56 0.76 0.64, 0.90 0.001 0.63
Nodal status         
 Node-negative 17,463 37,836 0.98 0.93, 1.03 0.47 0.86 0.71, 1.04 0.12  
 Node-positive 10,746 37,836 0.98 0.92, 1.04 0.46 0.72 0.57, 0.93 0.01  
 NK 9,359         
 Total 37,568 37,836 0.98 0.94, 1.02 0.31 0.81 0.68, 0.96 0.02 0.51
  1. Association of rs10235235 with risk of breast cancer for women of European ancestry stratified by oestrogen receptor (ER) status, progesterone receptor (PR) status, morphology, grade and nodal status. ORhet, odds ratio comparing rs10235235 AG genotype versus AA genotype; H0, null hypothesis; NK, not known; ORhom, odds ratio comparing rs10235235 GG genotype versus AA genotype; P1, test of H0 no association between rs10235235 and breast cancer risk; Phet, test of H0 no difference between stratum specific estimates for variables with two strata or test of H0 no linear trend in stratum specific estimates for variables with three strata. aExcludes seven studies that selected all ER-negative cases (CTS, DEMOKRITOS, NBCS, NBHS, OSU, RPCI and SKKDKFZS) and one study (PBCS) that selected all ER-positive cases. bExcludes seven studies that selected all PR-negative cases (CTS, DEMOKRITOS, NBCS, NBHS, OSU, RPCI and SKKDKFZS).