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Table 1 Association of rs10235235 with risk of breast cancer for women of European ancestry: stratified analysis

From: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

 

Cases

Controls

ORhet

95% CI

P 1

ORhom

95% CI

P 1

P het

ER status

         

 ER-positive

24,780

38,739

0.99

0.95, 1.03

0.61

0.83

0.70, 0.99

0.04

 

 ER-negative

5,851

38,739

1.02

0.95, 1.10

0.60

0.60

0.43, 0.86

0.005

 

 NK

8,339

        

 Total

38,970a

38,739

0.99

0.95, 1.03

0.74

0.79

0.67, 0.94

0.006

0.83

PR status

         

 PR-positive

18,497

39,033

0.98

0.93, 1.02

0.32

0.82

0.67, 0.99

0.04

 

 PR-negative

8,193

39,033

1.02

0.96, 1.09

0.53

0.74

0.56, 0.98

0.03

 

 NK

12,111

        

 Total

38,801b

39,033

0.99

0.94, 1.03

0.52

0.80

0.67, 0.95

0.01

0.19

Morphology

         

 Ductal

22,123

31,803

0.98

0.93, 1.02

0.30

0.74

0.61, 0.90

0.003

 

 Lobular

3,921

31,803

1.07

0.98, 1.17

0.14

0.91

0.64, 1.27

0.57

 

 Other and NK

5,995

        

 Total

32,039

31,803

0.99

0.95, 1.04

0.64

0.77

0.64, 0.92

0.004

0.03

Grade

         

 Grade 1

5,944

37,285

0.97

0.90, 1.05

0.46

0.86

0.65, 1.15

0.31

 

 Grade 2

13,427

37,285

1.00

0.95, 1.06

0.92

0.80

0.63, 0.98

0.04

 

 Grade 3

8,638

37,285

0.98

0.92, 1.05

0.58

0.61

0.46, 0.82

0.001

 

 NK

8,769

        

 Total

36,778

37,285

0.99

0.95, 1.03

0.56

0.76

0.64, 0.90

0.001

0.63

Nodal status

        

 Node-negative

17,463

37,836

0.98

0.93, 1.03

0.47

0.86

0.71, 1.04

0.12

 

 Node-positive

10,746

37,836

0.98

0.92, 1.04

0.46

0.72

0.57, 0.93

0.01

 

 NK

9,359

        

 Total

37,568

37,836

0.98

0.94, 1.02

0.31

0.81

0.68, 0.96

0.02

0.51

  1. Association of rs10235235 with risk of breast cancer for women of European ancestry stratified by oestrogen receptor (ER) status, progesterone receptor (PR) status, morphology, grade and nodal status. ORhet, odds ratio comparing rs10235235 AG genotype versus AA genotype; H0, null hypothesis; NK, not known; ORhom, odds ratio comparing rs10235235 GG genotype versus AA genotype; P1, test of H0 no association between rs10235235 and breast cancer risk; Phet, test of H0 no difference between stratum specific estimates for variables with two strata or test of H0 no linear trend in stratum specific estimates for variables with three strata. aExcludes seven studies that selected all ER-negative cases (CTS, DEMOKRITOS, NBCS, NBHS, OSU, RPCI and SKKDKFZS) and one study (PBCS) that selected all ER-positive cases. bExcludes seven studies that selected all PR-negative cases (CTS, DEMOKRITOS, NBCS, NBHS, OSU, RPCI and SKKDKFZS).
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Breast Cancer Research

ISSN: 1465-542X

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