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Figure 1 | Breast Cancer Research

Figure 1

From: Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer

Figure 1

Kaplan-Meier estimates of progression-free survival (PFS) by HER2 mRNA expression below the median and equal to or greater than median. (A) Kaplan-Meier estimates of PFS by investigator assessment in patients with expression of HER2 mRNA below the median. The hazard ratio for progression was 0.85 (95% CI 0.44, 1.67). (B) Kaplan-Meier estimates of PFS by investigator assessment in patients with expression of HER2 mRNA equal to or greater than the median. The hazard ratio for progression was 0.39 (95% CI 0.18, 0.85). HER2, human epidermal growth factor receptor 2; HR, hazard ratio; HT, trastuzumab plus docetaxel; mRNA, messenger RNA; NR, not reached; T-DM1, trastuzumab emtansine.

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