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Table 2 Multivariate analysis of factors associated with overall survival from death due to breast cancer (OS)

From: The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo

Single predictor

Number

Hazard ratio

95% CI

P

Age 50+ versus <50

420

1.67

0.74 to 3.81

0.22

Tumor >2.5 cm

422

2.27

1.56 to 3.30

<.0001

Node Pos versus Neg

415

2.06

1.42 to 3.00

0.0002

Grade (Low, Mid High)

420

1.38

1.02 to 1.87

0.035

PR_LBA >20

421

0.61

0.42 to 0.87

0.0068

P7 Score High

340

2.78

1.45 to 5.35

0.0022

pmTor >80

337

0.61

0.39 to 0.95

0.028

mTor >180

329

0.87

0.56 to 1.35

0.53

Multi predictor/Selection model

   

Age 50+ versus <50

277

0.93

0.33 to 2.68

0.90

Tumor >2.5 cm

 

1.98

1.23 to 3.21

0.0053

Node Pos versus Neg

 

1.92

1.14 to 3.26

0.015

Grade (Low, Mid High)

1.21

0.83 to 1.76

0.32

PR_LBA >20

 

0.70

0.44 to 1.11

0.12

P7 Score High

 

2.57

1.09 to 6.06

0.032

pmTor >80

 

0.95

0.58 to 1.55

0.84

  1. CI, confidence interval; mTOR, mechanistic target of rapamycin; PR_LBA, Progesterone Receptor Ligand Binding Assay.
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Breast Cancer Research

ISSN: 1465-542X

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