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Table 2 Multivariate analysis of factors associated with overall survival from death due to breast cancer (OS)

From: The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo

Single predictor Number Hazard ratio 95% CI P
Age 50+ versus <50 420 1.67 0.74 to 3.81 0.22
Tumor >2.5 cm 422 2.27 1.56 to 3.30 <.0001
Node Pos versus Neg 415 2.06 1.42 to 3.00 0.0002
Grade (Low, Mid High) 420 1.38 1.02 to 1.87 0.035
PR_LBA >20 421 0.61 0.42 to 0.87 0.0068
P7 Score High 340 2.78 1.45 to 5.35 0.0022
pmTor >80 337 0.61 0.39 to 0.95 0.028
mTor >180 329 0.87 0.56 to 1.35 0.53
Multi predictor/Selection model    
Age 50+ versus <50 277 0.93 0.33 to 2.68 0.90
Tumor >2.5 cm   1.98 1.23 to 3.21 0.0053
Node Pos versus Neg   1.92 1.14 to 3.26 0.015
Grade (Low, Mid High) 1.21 0.83 to 1.76 0.32
PR_LBA >20   0.70 0.44 to 1.11 0.12
P7 Score High   2.57 1.09 to 6.06 0.032
pmTor >80   0.95 0.58 to 1.55 0.84
  1. CI, confidence interval; mTOR, mechanistic target of rapamycin; PR_LBA, Progesterone Receptor Ligand Binding Assay.