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Table 1 Summary of secondary screen of TRAIL-induced caspase-3/7 activation

From: Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

Gene

MB231 (TNBC/Basal B)

MB468 (TNBC/Basal A)

T47D (ER+)

SKBR3 (HER2+)

ACTN4

+

+

+

+

BCL2L1

+

+

+

(+)

BIRC2

+

+

(+)

+

ATP5A

+

+

+

-

BCR

+

+

+

-

FGFR4

+

+

(+)

-

PDPK1

+

+

(+)

-

PIP5K1C

+

+

(+)

-

RIOK3

+

+

(+)

-

SRC

+

+

(+)

-

CNKSR1

+

+

-

-

HIPK2

(+)

+

-

-

MKNK1

(+)

+

-

-

PLK3

+

+

-

-

PRKC1

+

+

-

-

IKBKB

-

+

-

-

  1. + indicates that three or more siRNAs for a target enhanced TRAIL-induced caspase-3/7 activity by >2 standard deviations (criterion 1).
  2. (+) indicates three or more siRNAs for a target enhanced TRAIL-induced caspase-3/7 activity by >1 standard deviation (criterion 2).
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Breast Cancer Research

ISSN: 1465-542X

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