Skip to main content

Table 1 Summary of secondary screen of TRAIL-induced caspase-3/7 activation

From: Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

Gene MB231 (TNBC/Basal B) MB468 (TNBC/Basal A) T47D (ER+) SKBR3 (HER2+)
ACTN4 + + + +
BCL2L1 + + + (+)
BIRC2 + + (+) +
ATP5A + + + -
BCR + + + -
FGFR4 + + (+) -
PDPK1 + + (+) -
PIP5K1C + + (+) -
RIOK3 + + (+) -
SRC + + (+) -
CNKSR1 + + - -
HIPK2 (+) + - -
MKNK1 (+) + - -
PLK3 + + - -
PRKC1 + + - -
IKBKB - + - -
  1. + indicates that three or more siRNAs for a target enhanced TRAIL-induced caspase-3/7 activity by >2 standard deviations (criterion 1).
  2. (+) indicates three or more siRNAs for a target enhanced TRAIL-induced caspase-3/7 activity by >1 standard deviation (criterion 2).