Skip to main content

Table 3 Summary statistics of the reference values produced by three observers with the corresponding data of visual estimates and digital image analysis, n = 164

From: A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue

Variable

Median

Mean

Std dev

Std error

Min

Max

Ki67-Count

35.0

40.2

25.3

2.0

0.6

98.1

Ki67-DIA-2

30.1

36.5

20.2

1.6

6.4

93.0

Ki67-DIA-1

24.1

31.1

21.1

1.6

1.5

90.5

Ki67-DIA-0

20.4

25.9

18.1

1.4

2.1

85.7

Visual median

30

37.2

27.4

2.1

2

95

Visual mean

28.4

36.2

25.6

2.0

2.2

96.4

Ki67-VE-1

15

24.3

23.6

1.8

5

95

Ki67-VE-2

40

43.4

29.6

2.3

2

98

Ki67-VE-3

37.5

44.1

30.0

2.3

1

99

Ki67-VE-4

22

31.6

24.3

1.9

1

95

Ki67-VE-5

30

37.7

27.7

2.2

1

100

Total profiles observer*

2,372

2,658.7

1,390.4

108.6

464

7,452

Total profiles DIA-2

2,150.5

2,293.2

796.8

62.2

752

4,302

Total profiles DIA-1

1,920.5

2,022.7

670.1

52.3

1,012

3,788

Total profiles DIA-0

4,203.5

4,385.0

1,420.2

110.9

1,640

7,939

  1. *Total nuclear profiles observer counts are multiplied by four in this table to be comparable to the DIA total profile numbers (the box grid used for the observer count covers ne-fourth of the image area). DIA, digital image analysis; VE, visual estimate.