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Table 3 Summary statistics of the reference values produced by three observers with the corresponding data of visual estimates and digital image analysis, n = 164

From: A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue

Variable Median Mean Std dev Std error Min Max
Ki67-Count 35.0 40.2 25.3 2.0 0.6 98.1
Ki67-DIA-2 30.1 36.5 20.2 1.6 6.4 93.0
Ki67-DIA-1 24.1 31.1 21.1 1.6 1.5 90.5
Ki67-DIA-0 20.4 25.9 18.1 1.4 2.1 85.7
Visual median 30 37.2 27.4 2.1 2 95
Visual mean 28.4 36.2 25.6 2.0 2.2 96.4
Ki67-VE-1 15 24.3 23.6 1.8 5 95
Ki67-VE-2 40 43.4 29.6 2.3 2 98
Ki67-VE-3 37.5 44.1 30.0 2.3 1 99
Ki67-VE-4 22 31.6 24.3 1.9 1 95
Ki67-VE-5 30 37.7 27.7 2.2 1 100
Total profiles observer* 2,372 2,658.7 1,390.4 108.6 464 7,452
Total profiles DIA-2 2,150.5 2,293.2 796.8 62.2 752 4,302
Total profiles DIA-1 1,920.5 2,022.7 670.1 52.3 1,012 3,788
Total profiles DIA-0 4,203.5 4,385.0 1,420.2 110.9 1,640 7,939
  1. *Total nuclear profiles observer counts are multiplied by four in this table to be comparable to the DIA total profile numbers (the box grid used for the observer count covers ne-fourth of the image area). DIA, digital image analysis; VE, visual estimate.