Comparisona | Cancer-specific deaths | Controls | OR (95% CI) low dose aspirin exposed vs. non-exposed | P | OR (95% CI) 1 to 11 low dose aspirin prescriptions vs. none | P | OR (95% CI) 12 or more low dose aspirin prescriptions vs. none | P |
---|---|---|---|---|---|---|---|---|
Main analysis: Diagnosis to six months prior to death | 1,435 | 5,697 | 0.98 (0.83, 1.15) | 0.77 | 0.88 (0.71, 1.09) | 0.25 | 1.08 (0.87, 1.33) | 0.48 |
Post diagnostic aspirin in patients with no pre-diagnostic aspirin prescriptionsb | 1,125 | 4,457 | 0.82 (0.64, 1.04) | 0.10 | 0.81 (0.59, 1.10) | 0.17 | 0.84 (0.59, 1.18) | 0.31 |
Post diagnostic aspirin in patients with pre-diagnostic aspirin prescriptionsb | 142 | 515 | 0.95 (0.52, 1.71) | 0.86 | 0.82 (0.43, 1.56) | 0.55 | 1.08 (0.57, 2.03) | 0.81 |
Pre-diagnostic low dose aspirin prescriptionsc | 1,559 | 6,186 | 0.99 (0.83, 1.18) | 0.93 | 1.01 (0.83, 1.22) | 0.93 | 0.94 (0.67, 1.32) | 0.71 |
Diagnosis to one year prior to deathd | 1,272 | 5,048 | 1.06 (0.89, 1.26) | 0.51 | 1.01 (0.80, 1.27) | 0.95 | 1.11 (0.89, 1.40) | 0.36 |
Diagnosis to two years prior to deathe | 959 | 3,797 | 0.89 (0.72, 1.10) | 0.28 | 0.62 (0.46, 0.85) | 0.003 | 1.22 (0.93, 1.60) | 0.15 |
One year after diagnosis to six months prior to deathf | 1,099 | 4,356 | 0.93 (0.77, 1.12) | 0.43 | 0.84 (0.65, 1.09) | 0.20 | 1.01 (0.79, 1.29) | 0.94 |
Stage 1 and 2 breast cancer patients only | 469 | 1,856 | 1.09 (0.82, 1.46) | 0.54 | 0.83 (0.55, 1.24) | 0.36 | 1.41 (0.98, 2.04) | 0.07 |
Stage 3 and 4 breast cancer patients only | 161 | 478 | 1.13 (0.68, 1.86) | 0.64 | 1.24 (0.66, 2.33) | 0.50 | 0.98 (0.45, 2.12) | 0.96 |
Restricted to patients receiving prescriptions for hormone therapy (in first six months) | 875 | 3,466 | 1.08 (0.90, 1.30) | 0.43 | 0.93 (0.72, 1.20) | 0.55 | 1.23 (0.97, 1.56) | 0.08 |
Patients with a recorded stage from cancer registries with high rates of stage recording (adjusted for stage)g | 487 | 1,911 | 0.92 (0.67, 1.27) | 0.62 | 0.95 (0.62, 1.45) | 0.81 | 0.90 (0.59, 1.37) | 0.62 |
Including breast cancer-specific deaths where breast cancer is recorded as any cause of death | 1,786 | 7,090 | 1.05 (0.91, 1.20) | 0.53 | 1.01 (0.84, 1.21) | 0.95 | 1.09 (0.91, 1.30) | 0.37 |
Time varying covariate analysish | 1,440 | 8,374 | 1.06 (0.92, 1.22) | 0.45 | 0.98 (0.81, 1.20) | 0.88 | 1.13 (0.94, 1.35) | 0.20 |
Time varying covariate analysisi | 1,440 | 8,374 | 1.04 (0.90, 1.20) | 0.60 | 0.96 (0.79, 1.67) | 0.67 | 1.12 (0.93, 1.35) | 0.22 |