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Figure 3 | Breast Cancer Research

Figure 3

From: Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways

Figure 3

RIP2 mRNA expression in primary tumors suggests correlation with extensive axillary lymph node invasion in stage III breast cancer. (A) RIP2 mRNA fluorescence in situ hybridization (FISH) in primary breast tissue of a representative patient with N3 (top panels) and N0 (bottom panels) breast cancer. Scale bar = 20 μM. (B) Average number of cytoplasmic mRNA foci per 50 cells was used to compare the group of stage-III patients from the University of Texas Southwestern Medical Center (UTSW) Tissue Repository with extensive (N3) versus limited (N0, N1) lymph node involvement. Average of three imaging fields per case with error bars representing standard error of the mean (SEM). (C) Relative RIP2 expression of stage-III patients from The Cancer Genome Atlas (TCGA) with N3 versus N0/N1 disease. Statistics per two-sided Student t-test for B, C. (D) Kaplan-Meier estimator to evaluate RIP2 expression and lymph node status as prognostic indicator in the combined public expression array datasets. PFS, progression-free survival.

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Breast Cancer Research

ISSN: 1465-542X

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