Skip to main content
Figure 3 | Breast Cancer Research

Figure 3

From: A BRCA1deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity

Figure 3

Distribution of BD-L value by ER and HER2 status. Dot plot and box plot distribution of BD-L metagene values by ER and HER2 status and correlation with clinical outcome in the (A) NKI295, (B) EMC286/MSK82, and (C) EMC192 cohorts. Statistically significant differences in BD-L metagene values were observed for ER-/HER- primary tumors when compared to ER+/HER2+ (P value = (A) 4.5 × 10-6, (B) 0.0025, (C) 2.8 × 10-5) and ER+/HER2- (P value = (A) 1.1 × 10-13, (B) 4 × 10-8, (C) 8.7 × 10-10) subgroups. BD-L, BRCA1 Deficient-Like; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2.

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us