BD-L metagene values in primary and metastatic specimens. Values in primary breast cancer and metastatic breast cancer samples as calculated from a previously described cohort detailed in Zhang et al. . (A) Dot plot of individual metagene values. (B) Box plot of metagene values. Statistically significant differences in BD-L metagene value were observed for the brain metastases when compared to primary tumors (P value = 0.0043), bone metastases (P value = 4 × 10-6), and lung metastases (P value = 0.001). BD-L, BRCA1 Deficient-Like.