Figure 2
From: Trastuzumab emtansine: mechanisms of action and drug resistance
Histological findings in a human epidermal growth factor receptor-2-positive, trastuzumab and lapatinib-resistant breast cancer (JIMT-1) xenograft following trastuzumab emtansine treatment. Numerous apoptotic cells are present (stained brown with CytoDeath staining). Hematoxylin counterstain reveals multinucleated giant cells and pathological mitoses (arrows), which are hallmarks of mitotic catastrophe. Mitotic catastrophes were absent in trastuzumab-treated tumors.