Table 3 Risk of invasive or in situ breast cancer in relation to duration between pubertal events
From: Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study
Adjusted for attained age | Multivariate-adjusteda | |||||
|---|---|---|---|---|---|---|
Pubertal variable | Ncases/person-years | HR (95% CI) | Ncases/person-years | HR (95% CI) | ||
Thelarche to menarche, years | ||||||
<0 | 57/27,759 | 0.85 (0.64,1.13) | 57/27,381 | 0.87 (0.65,1.15) | ||
0 | 275/112,810 | Referent | 271/111,168 | Referent | ||
1 | 303/116,433 | 1.14 (0.97,1.34) | 299/114,967 | 1.14 (0.96,1.34) | ||
≥2 | 156/61,061 | 1.27 (1.05,1.55) | * | 155/60,301 | 1.27 (1.04,1.55) | * |
P for trend | 1.14 (1.05, 1.23) | ** | 1.13 (1.05, 1.23) | ** | ||
Thelarche to regular periods, years | ||||||
<0 | 24/9,864 | 0.88 (0.57,1.36) | 24/9,734 | 0.89 (0.58,1.38) | ||
0 | 129/46,383 | Referent | 127/45,750 | Referent | ||
1 | 179/71,457 | 0.93 (0.74,1.16) | 177/70,595 | 0.92 (0.73,1.15) | ||
≥2 | 188/81,162 | 0.94 (0.75,1.18) | 187/80,149 | 0.93 (0.74,1.16) | ||
Never became | 73/26,114 | 1.19 (0.89,1.59) | 73/25,581 | 1.19 (0.89,1.58) | ||
regular | ||||||
P for trendb | 0.99 (0.90, 1.09) | 0.98 (0.89, 1.08) | ||||
Menarche to regular periods, years | ||||||
0 | 379/134,744 | Referent | 376/132,702 | Referent | ||
1 | 180/71,866 | 0.88 (0.74,1.06) | 178/70,749 | 0.87 (0.73,1.04) | ||
≥2 | 54/31,244 | 0.67 (0.51,0.90) | ** | 54/30,778 | 0.66 (0.50,0.88) | ** |
Never became | 73/26,114 | 1.14 (0.89,1.47) | 73/25,581 | 1.13 (0.88,1.46) | ||
regular | ||||||
P for trendb | 0.84 (0.75, 0.95) | ** | 0.84 (0.74, 0.94) | ** | ||
Menarche to adult height, years | ||||||
<0 | 14/5,941 | 0.90 (0.52,1.56) | 14/5,871 | 0.90 (0.52,1.57) | ||
0 to 1 | 131/50,937 | Referent | 130/50,492 | Referent | ||
2-3 | 191/83,968 | 0.98 (0.79,1.23) | 189/82,911 | 0.96 (0.77,1.21) | ||
≥4 | 165/78,925 | 0.94 (0.75,1.19) | 165/77,560 | 0.94 (0.75,1.19) | ||
P for trend | 0.98 (0.89, 1.09) | 0.98 (0.88, 1.09) | ||||