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Figure 3 | Breast Cancer Research

Figure 3

From: Identification and characterization of locus-specific methylation patterns within novel loci undergoing hypermethylation during breast cancer pathogenesis

Figure 3

Examples of the overall methylation screening results in cases and controls illustrating a shift in methylation of the locus during carcinogenesis. Standards: 100% methylated (red), 10% methylated in a background of unmethylated template (blue), 1% methylated (yellow) and unmethylated standard (green). Melting peaks were generated by taking the negative derivative (d) of the melting curve data divided by the derivative with respect to time -(d/dT). Each panel displays 20 methylation-sensitive high-resolution melting scans. (A) and (B) BC008699 assay. (C) and (D) SIX6 assay. Scans from control samples are shown in (A) and (C). (B) and (D) show HRM scans of the cancer tissue samples.

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Breast Cancer Research

ISSN: 1465-542X

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