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Figure 1 | Breast Cancer Research

Figure 1

From: Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci

Figure 1

Number of breast cancer risk GWA study nominated SNPs mapping to rat Mcs/Mcsm regions. Number of GWA study nominated SNPs mapping to orthologs of rat Mcs/Mcsm loci and rat random regions. Dark grey columns represent the number of GWA study nominated human SNPs mapping to the human orthologous regions of the Mcs/Mcsm loci. Light grey columns represent the number of GWA study nominated human SNPs mapping to the human orthologous regions of the random rat control regions. The difference between risk associated SNPs mapping to rat Mcs/Mcsm and random rat regions was statistically significant for European populations. Asterisk indicates P-value <0.05 using chi-square analysis with number of SNPs mapping to Mcs/Mcsm set as the observed value and number of SNPs mapping to random rat regions as the expected value. GWA, genome-wide association.

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Breast Cancer Research

ISSN: 1465-542X

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