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Table 2 Associations between HER2, PTEN, IGF-1R, and clinico-pathologic variables

From: PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients

 

HER2 status

 

PTEN

 

IGF-1-R

 

Negative

Positive

 

Negative

Positive

 

Low (0–2)

High (3)

 
 

n(%)

n(%)

Pvalue

n(%)

n(%)

Pvalue

n(%)

n(%)

P-value

Age

<65

233 (48)

18 (44)

0.75

39 (48)

164 (46)

0.90

190 (47)

19 (49)

1.00

≥65

256 (52)

23 (56)

43 (52)

190 (54)

210 (53)

20 (51)

Lymph node status

Negative

276 (56)

16 (39)

0.03

42 (51)

189 (53)

0.81

211 (53)

22 (56)

0.74

Positive

213 (44)

25 (61)

40 (49)

165 (47)

189 (47)

17 (44)

T stage

T1-2

437 (89)

34 (83)

0.20

70 (85)

317 (89)

0.33

354 (89)

31 (80)

0.12

T3-4

52 (11)

7 (17)

12 (15)

37 (11)

46 (11)

8 (20)

Grade

Grade 1-2

342 (70)

9 (22)

<0.001

45 (55)

226 (64)

0.16

250 (63)

26 (67)

0.73

Grade 3

147 (30)

32 (78)

37 (45)

128 (36)

150 (37)

13 (33)

Progesterone receptor a

Negative

222 (45)

30 (73)

0.001

49 (60)

163 (46)

0.03

194 (49)

18 (46)

1.00

Positive

261 (53)

11 (27)

32 (39)

190 (54)

205 (51)

20 (51)

Missing

6 (1)

0 (0)

1 (1)

1 (0)

1 (0)

1 (3)

HER2 a

Negative

489 (100)

0 (0)

na

77 (94)

313 (88)

0.08

357 (89)

36 (92)

0.56

Positive

0 (0)

41 (100)

3 (4)

36 (10)

36 (9)

2 (5)

 

Missing

na

na

 

2 (2)

5 (1)

 

7 (2)

1 (3)

 
  1. aOnly cases without missing values were analyzed.