| HER2 status |  | PTEN |  | IGF-1-R |  | ||||
---|---|---|---|---|---|---|---|---|---|---|
Negative | Positive |  | Negative | Positive |  | Low (0–2) | High (3) |  | ||
 | n(%) | n(%) | Pvalue | n(%) | n(%) | Pvalue | n(%) | n(%) | P-value | |
Age | <65 | 233 (48) | 18 (44) | 0.75 | 39 (48) | 164 (46) | 0.90 | 190 (47) | 19 (49) | 1.00 |
≥65 | 256 (52) | 23 (56) | 43 (52) | 190 (54) | 210 (53) | 20 (51) | ||||
Lymph node status | Negative | 276 (56) | 16 (39) | 0.03 | 42 (51) | 189 (53) | 0.81 | 211 (53) | 22 (56) | 0.74 |
Positive | 213 (44) | 25 (61) | 40 (49) | 165 (47) | 189 (47) | 17 (44) | ||||
T stage | T1-2 | 437 (89) | 34 (83) | 0.20 | 70 (85) | 317 (89) | 0.33 | 354 (89) | 31 (80) | 0.12 |
T3-4 | 52 (11) | 7 (17) | 12 (15) | 37 (11) | 46 (11) | 8 (20) | ||||
Grade | Grade 1-2 | 342 (70) | 9 (22) | <0.001 | 45 (55) | 226 (64) | 0.16 | 250 (63) | 26 (67) | 0.73 |
Grade 3 | 147 (30) | 32 (78) | 37 (45) | 128 (36) | 150 (37) | 13 (33) | ||||
Progesterone receptor a | Negative | 222 (45) | 30 (73) | 0.001 | 49 (60) | 163 (46) | 0.03 | 194 (49) | 18 (46) | 1.00 |
Positive | 261 (53) | 11 (27) | 32 (39) | 190 (54) | 205 (51) | 20 (51) | ||||
Missing | 6 (1) | 0 (0) | 1 (1) | 1 (0) | 1 (0) | 1 (3) | ||||
HER2 a | Negative | 489 (100) | 0 (0) | na | 77 (94) | 313 (88) | 0.08 | 357 (89) | 36 (92) | 0.56 |
Positive | 0 (0) | 41 (100) | 3 (4) | 36 (10) | 36 (9) | 2 (5) | ||||
 | Missing | na | na |  | 2 (2) | 5 (1) |  | 7 (2) | 1 (3) |  |