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Figure 8 | Breast Cancer Research

Figure 8

From: Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro

Figure 8

Greater inhibition of TamR (A) and MCF7-X (B) cell growth by the pure anti-oestrogen fulvestrant is apparent when the drug is used in combination with AZD8055. TamR cells were grown for seven days in the absence of tamoxifen. TamR and MCF7-X cells were then grown for seven days in the presence of fulvestrant (10-7 M) and AZD8055 (0 to 25 nM). Cells were counted and the results expressed as a percentage of the untreated control. Results are means of four independent experiments. Statistical analyses used ANOVA with a post hoc test to compare doses of AZD8055 plus fulvestrant versus AZD8055 alone and AZD8055 plus fulvestrant versus the fulvestrant alone control (0). *P <0.05, **P <0.01, ***P <0. 001. ANOVA, analysis of variance.

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