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Figure 5 | Breast Cancer Research

Figure 5

From: Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in mammary tumour progression

Figure 5

Doxycycline withdrawal in rtTA/MIC tumours leads to rapid regression and eventual spontaneous recurrence of masses. (A) Total mammary tumour burden measured over time in rtTA/MIC mice prior to and following doxycycline withdrawal (indicated by the dotted line at time 0). Tumour-bearing mice were de-induced upon reaching burden endpoint. Each line represents an individual animal labeled by its ID number. (B) Quantification of the number of measurable masses detected pre-regression (pre), at the point of maximum regression (mid) and at sacrifice (recurrent). Bars represent the average value at each time-point. **P <0.01.

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Breast Cancer Research

ISSN: 1465-542X

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