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Figure 1 | Breast Cancer Research

Figure 1

From: Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in mammary tumour progression

Figure 1

Induced rtTA/MIC animals develop mammary tumours with characteristic histopathological features of PyV mT-driven mammary tumourigenesis. (A) Kaplan-Meier mammary tumour onset curve as measured by physical palpation. A total of 87.1% (34/39) of mice developed multifocal mammary tumours with a T50 of 7 days and an average of 22.0 ± 7.1 days post-induction with doxycycline. Control animals (induced rtTA or MIC; un-induced rtTA/MIC) were monitored for at least one year. (B) Representative H&E-stained sections of normal ductal structures in a mammary gland from a control animal (an un-induced rtTA/MIC) followed by typical stages of PyV mT mammary tumour progression (hyperplasia, mammary intraepithelial neoplasia (MIN), and adenocarcinoma) in mammary glands and tumours from rtTA/MIC mice following doxycycline induction. (Scale bar: 100 μm).

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