Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2

Breast Cancer Research

Table 1 Vaccination of FVB-huHER2 mice started at different ages: effect on induction of anti-huHER2 antibody levels at 4 weeks after first vaccination ^a

Vaccine	Start of vaccination (weeks of age)	Number of mice	Anti-huHER2 antibodies (ng/ml), mean ± standard error
HER2-cell	5 to 7	9	1,121 ± 347
	8 to 12	6	720 ± 327
	18 to 20	4	692 ± 243
	24 to 26	6	1,107 ± 123
HuRT-DNA	11 to 15	6	1,671 ± 440*
	18 to 20	6	5,297 ± 1,284
	24 to 26	5	667 ± 277*

^aFVB-huHER2, FVB mice transgenic for huHER2; huHER2, human HER2 gene. *P = 0.02 vs. HuRT-DNA at 18 to 20 weeks (Student’s t-test).

ISSN: 1465-542X