Table 1 Examples of BRCA1 and BRCA2 founder mutations
From: Founder populations and their uses for breast cancer genetics
Population | Mutation | Reference |
|---|---|---|
African-Americans | BRCA1 943ins10 | |
| Â | BRCA1 M1775R | Â |
Ashkenazi Jews | BRCA1 185delAG | |
| Â | BRCA1 5382insC | Â |
| Â | BRCA2 6174delT | Â |
Belgians | BRCA1 IVS5 +3A>G | [42] |
Dutch | BRCA1 2804delAA | |
| Â | BRCA1 IVS 21-36del510 | Â |
| Â | BRCA1 IVS 12-1643 del3835 | Â |
| Â | BRCA2 5573insA | Â |
Finns | BRCA1 3745delT | [27] |
| Â | BRCA1 IVS 11-2 A>G | Â |
| Â | BRCA2 999del5 | Â |
| Â | BRCA2 IVS23-2A>G | Â |
French-Canadians | BRCA1 R1443X | |
| Â | BRCA2 8765delAG | Â |
Germans | BRCA1 5382insC | [45] |
| Â | BRCA1 C61G | Â |
Icelanders | BRCA2 999del5 | [28] |
Latvians | BRCA1 C61G | [46] |
| Â | BRCA1 5382insC | Â |
| Â | BRCA1 4153delA | Â |
Norwegians | BRCA1 1675delA | |
| Â | BRCA1 1135insA | Â |
Russians | BRCA1 5382insC | [50] |
| Â | BRCA1 4153delA | Â |
Swedes | BRCA1 Q563X | [51] |
| Â | BRCA1 3166ins5 | Â |
| Â | BRCA1 1201del11 | Â |
| Â | BRCA1 2594delC | Â |
| Â | BRCA2 4486delG | Â |