Phosphorylated p-70S6K predicts tamoxifen resistance in postmenopausal breast cancer patients randomized between adjuvant tamoxifen versus no systemic treatment

Table 3 Adjusted hazard ratios for recurrence-free interval according to PI3K and/or MAPK pathway markers in patients who did not receive adjuvant systemic treatment

	Number of cases in analysis (events)	Hazard ratio^a	95% confidence interval	P value
p-AKT(Ser 473), (2 to 3) versus (0 to 1)	86 (27)	0.30	0.12 to 0.76	0.01
p-AKT(Thr308), positive versus negative	100 (26)	0.30	0.11 to 0.80	0.02
p-mTOR, high (≥60% ) versus low (0 to 59% )	94 (26)	0.11	0.02 to 0.55	0.007
p-ERK1/2, positive versus negative	94 (26)	0.52	0.22 to 1.24	0.14
p-p70S6K, positive versus negative	94 (25)	0.11	0.04 to 0.32	<0.0001

ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycine; PI3K, phosphatidylinositol-3-kinase; p, phosphorylated. ^aFor each marker, Cox proportional hazard models were performed with co-variables: lymph node status, age, tumor size, grade and progesterone receptor.

ISSN: 1465-542X