Table 2 Correlation coefficients (ρ) and levels of significance ( P ) between concentration of Cho, PCho, and GPC, and expression of genes contributing in the choline metabolism pathway
From: Interplay of choline metabolites and genes in patient-derived breast cancer xenografts
Subgroup | Metabolite | Gene | ρ | P-value |
|---|---|---|---|---|
All samples (N = 30) | Cho | CHPT1 | 0.49 | 0.008 |
PLA2G1B | 0.43 | 0.021 | ||
PNPLA6 | 0.41 | 0.028 | ||
PCho | CHKA | 0.43 | 0.021 | |
GDPD5 | 0.38 | 0.041 | ||
GPC | CHKA | 0.44 | 0.017 | |
GDPD5 | 0.56 | 0.002 | ||
LYPLA1 | -0.40 | 0.030 | ||
PLA2G6 | 0.43 | 0.021 | ||
PLCD1 | 0.37 | 0.045 | ||
PLD3 | -0.42 | 0.024 | ||
PNPLA7 | 0.39 | 0.035 | ||
Basal-like (N = 19) | Cho | CHKA | 0.46 | 0.049 |
CHPT1 | 0.50 | 0.029 | ||
PLA2G10 | 0.53 | 0.021 | ||
PLA2G6 | 0.61 | 0.006 | ||
PCho | CHKA | 0.47 | 0.044 | |
PLA2G2E | -0.52 | 0.024 | ||
PLCB4 | 0.51 | 0.027 | ||
GPC | CHKA | 0.52 | 0.023 | |
GDPD5 | 0.73 | <0.001 | ||
PCYT1B | 0.49 | 0.035 | ||
PLA2G6 | 0.67 | 0.002 | ||
PNPLA7 | 0.52 | 0.021 | ||
Luminal B (N = 6) | Cho | CHKB | -0.96 | 0.002 |
PLA2G12B | -0.91 | 0.012 | ||
PLA2G4A | 0.86 | 0.029 | ||
PLCD3 | -0.86 | 0.027 | ||
PCho | PLCB1 | -0.91 | 0.011 | |
PLD1 | 0.89 | 0.017 | ||
GPC | CHKB | -0.97 | 0.001 | |
PLCD3 | -0.81 | 0.049 | ||
SLC22A2 | -0.86 | 0.030 |