Table 4 Distribution of tumor phenotypes among screening-detected cancers (n = 1,297) and categories of interval cancers (n = 948) stratified by breast density
Breast density | |||||
|---|---|---|---|---|---|
<25% | 25 to 50% | 50 to 75% | >75% | P-value† | |
Tumor phenotype | |||||
Screening-detected cancers | |||||
Luminal A | 247 (68.6) | 165 (65.5) | 142 (70.3) | 75 (71.4) | |
Luminal B | 51 (36.7) | 49 (19.3) | 24 (11.9) | 15 (14.3) | |
HER2 | 20 (5.6) | 16 (6.3) | 17 (8.4) | 9 (8.6) | |
Triple negative | 42 (11.7) | 24 (9.4) | 19 (9.4) | 6 (5.7) | |
Unknown | 150 | 105 | 25 | 46 | 0.306 |
True interval cancers | |||||
Luminal A | 60 (52.2) | 51 (45.5) | 49 (50.5) | 37 (58.7) | |
Luminal B | 13 (11.3) | 17 (15.2) | 15 (15.5) | 15 (23.8) | |
HER2 | 9 (7.8) | 20 (17.9) | 22 (22.7)* | 2 (3.2)* | |
Triple negative | 33 (28.7)* | 24 (21.4) | 11 (11.3) | 9 (14.3) | |
Unknown | 24 | 15 | 17 | 12 | <0.001 |
False negatives | |||||
Luminal A | 40 (62.5) | 39 (75.0) | 22 (64.7) | 23 (71.9) | |
Luminal B | 10 (15.6) | 4 (7.7) | 9 (26.5) | 6 (18.8) | |
HER2 | 6 (9.4) | 4 (7.7) | 2 (5.9) | 2 (6.3) | |
Triple negative | 8 (12.5) | 5 (9.6) | 1 (2.9) | 1 (3.1) | |
Unknown | 17 | 8 | 11 | 6 | 0.375 |
Minimal-sign cancers | |||||
Luminal A | 30 (60.0) | 26 (66.7) | 16 (55.2) | 7 (46.7) | |
Luminal B | 6 (12.0) | 3 (7.7) | 5 (17.2) | 4 (26.7) | |
HER2 | 2 (4.0) | 5 (12.8) | 2 (6.9) | 4 (26.7) | |
Triple negative | 12 (24.0) | 5 (12.8) | 6 (20.7) | 0 (0) | |
Unknown | 14 | 8 | 10 | 1 | 0.081 |
Occult tumors | |||||
Luminal A | 8 (80.0) | 12 (80.0) | 26 (78.8) | 16 (80.0) | |
Luminal B | 0 (0) | 2 (13.3) | 4 (12.1) | 2 (10.0) | |
HER2 | 0 (0) | 1 (6.7) | 0 (0) | 2 (10.0) | |
Triple negative | 2 (20.0) | 0 (0) | 3 (9.1) | 0 (0) | |
Unknown | 5 | 5 | 6 | 9 | 0.296 |