Screening-detected cancers | True interval cancers | False negatives | Minimal-sign cancers | Occult tumors | ||
---|---|---|---|---|---|---|
n = 1,297 | n = 455 | n = 224 | n = 166 | n = 103 | P-value† | |
Interval cancer entities, n (%) ‡ | 455 (48.0) | 224 (23.6) | 166 (17.5) | 103 (10.9) | ||
Time since last screening, n (%) | ||||||
<=12 months | 89 (19.6) | 73 (32.7) | 53 (32.1) | 44 (42.7) | ||
>12 months | 364 (80.4) | 150 (67.3) | 112 (67.9) | 59 (57.3) | <0.001 | |
Age, y, mean (95% CI) | 57.6 (57.3, 57.9) | 56.4 (55.9, 57.0) | 57.4 (56.6, 58.1) | 56.8 (56.0, 57.6) | 55.1 (54.0, 56.2) | <0.001 |
Tumor size, mm, mean (95% CI) | 15.7 (15.1, 16.3) | 25.3 (23.6, 26.9) | 23.9 (22.1, 25.8) | 22.7 (20.5, 24.8) | 19.3 (17.0, 21.6) | <0.001 |
Focality, n (%) | ||||||
Unifocal | 1030 (82.8) | 341 (79.1) | 171 (78.4) | 118 (74.7) | 83 (85.6) | |
Multifocal and/or multicentric | 214 (17.2) | 90 (20.9) | 47 (21.6) | 40 (25.3) | 14 (14.4) | 0.041 |
Unknown | 53 | 24 | 6 | 8 | 6 | |
Tumor size, n (%) | ||||||
<= 10 mm | 452 (34.8)* | 36 (7.9)* | 18 (8.0)* | 22 (13.3)* | 13 (12.6)* | |
11 to 20 mm | 521 (40.2) | 147 (32.3) | 79 (35.3) | 53 (31.9) | 45 (43.7) | |
21 to 50 mm | 233 (18.0)* | 171 (37.6)* | 78 (34.8)* | 62 (37.3)* | 23 (22.3) | |
>50 mm | 91 (7.0)* | 101 (22.2)* | 49 (21.9)* | 29 (17.5) | 22 (21.4)* | <0.001 |
Unknown | 0 | 0 | 0 | 0 | 0 | |
Lymph node involvement, n (%) | ||||||
Negative | 872 (70.2)* | 195 (50.4)* | 102 (54.5) | 76 (49.7)* | 54 (62.1) | |
Positive | 371 (29.8)* | 192 (49.6)* | 85 (45.5) | 77 (50.3)* | 33 (37.9) | <0.001 |
Unknown | 54 | 68 | 37 | 13 | 16 | |
Histological type, n (%) | ||||||
Ductal | 1039 (80.5) | 349 (77.6) | 165 (74.0) | 129 (77.7) | 70 (68.6) | |
Lobular | 109 (8.4)* | 54 (12.0) | 36 (16.1)* | 16 (9.6) | 21 (20.6)* | |
Other | 143 (11.1) | 47 (10.4) | 22 (9.9) | 21 (12.7) | 11 (10.8) | <0.001 |
Unknown | 6 | 5 | 1 | 0 | 1 | |
Histological grade, n (%) | ||||||
I | 390 (34.9)* | 57 (14.9)* | 41 (21.4) | 33 (22.9) | 19 (22.6) | |
II | 474 (42.4) | 149 (39.0) | 88 (45.8) | 62 (43.1) | 42 (50.0) | |
III | 241 (21.6)* | 171 (44.8)* | 61 (31.8) | 47 (32.6) | 20 (23.8) | |
NA | 13 (1.2) | 5 (1.3) | 2 (1.0) | 2 (1.4) | 3 (3.6) | <0.001 |
Breast density, n (%) | ||||||
<25% | 510 (39.3)* | 139 (30.5)* | 81 (36.2) | 64 (38.6) | 15 (14.6)* | |
25 to 50% | 359 (27.7) | 127 (27.9) | 60 (26.8) | 47 (28.3) | 20 (19.4) | |
51 to 75% | 277 (21.4)* | 114 (25.1) | 45 (20.1) | 39 (23.5) | 39 (37.9)* | |
>75% | 151 (11.6) | 75 (16.5) | 38 (17.0) | 16 (9.6) | 29 (28.2)* | <0.001 |
Unknown | 0 | 0 | 0 | 0 | 0 |