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Table 1 Comparison of age at diagnosis and tumor characteristics at diagnosis between screening-detected cancers (n = 1,297) and interval cancers (n = 948)

From: Tumor phenotype and breast density in distinct categories of interval cancer: results of population-based mammography screening in Spain

 

Screening-detected cancers

True interval cancers

False negatives

Minimal-sign cancers

Occult tumors

 
 

n = 1,297

n = 455

n = 224

n = 166

n = 103

P-value

Interval cancer entities, n (%)

 

455 (48.0)

224 (23.6)

166 (17.5)

103 (10.9)

 

Time since last screening, n (%)

      

<=12 months

 

89 (19.6)

73 (32.7)

53 (32.1)

44 (42.7)

 

>12 months

 

364 (80.4)

150 (67.3)

112 (67.9)

59 (57.3)

<0.001

Age, y, mean (95% CI)

57.6 (57.3, 57.9)

56.4 (55.9, 57.0)

57.4 (56.6, 58.1)

56.8 (56.0, 57.6)

55.1 (54.0, 56.2)

<0.001

Tumor size, mm, mean (95% CI)

15.7 (15.1, 16.3)

25.3 (23.6, 26.9)

23.9 (22.1, 25.8)

22.7 (20.5, 24.8)

19.3 (17.0, 21.6)

<0.001

Focality, n (%)

      

Unifocal

1030 (82.8)

341 (79.1)

171 (78.4)

118 (74.7)

83 (85.6)

 

Multifocal and/or multicentric

214 (17.2)

90 (20.9)

47 (21.6)

40 (25.3)

14 (14.4)

0.041

Unknown

53

24

6

8

6

 

Tumor size, n (%)

      

<= 10 mm

452 (34.8)*

36 (7.9)*

18 (8.0)*

22 (13.3)*

13 (12.6)*

 

11 to 20 mm

521 (40.2)

147 (32.3)

79 (35.3)

53 (31.9)

45 (43.7)

 

21 to 50 mm

233 (18.0)*

171 (37.6)*

78 (34.8)*

62 (37.3)*

23 (22.3)

 

>50 mm

91 (7.0)*

101 (22.2)*

49 (21.9)*

29 (17.5)

22 (21.4)*

<0.001

Unknown

0

0

0

0

0

 

Lymph node involvement, n (%)

      

Negative

872 (70.2)*

195 (50.4)*

102 (54.5)

76 (49.7)*

54 (62.1)

 

Positive

371 (29.8)*

192 (49.6)*

85 (45.5)

77 (50.3)*

33 (37.9)

<0.001

Unknown

54

68

37

13

16

 

Histological type, n (%)

      

Ductal

1039 (80.5)

349 (77.6)

165 (74.0)

129 (77.7)

70 (68.6)

 

Lobular

109 (8.4)*

54 (12.0)

36 (16.1)*

16 (9.6)

21 (20.6)*

 

Other

143 (11.1)

47 (10.4)

22 (9.9)

21 (12.7)

11 (10.8)

<0.001

Unknown

6

5

1

0

1

 

Histological grade, n (%)

      

I

390 (34.9)*

57 (14.9)*

41 (21.4)

33 (22.9)

19 (22.6)

 

II

474 (42.4)

149 (39.0)

88 (45.8)

62 (43.1)

42 (50.0)

 

III

241 (21.6)*

171 (44.8)*

61 (31.8)

47 (32.6)

20 (23.8)

 

NA

13 (1.2)

5 (1.3)

2 (1.0)

2 (1.4)

3 (3.6)

<0.001

Breast density, n (%)

      

<25%

510 (39.3)*

139 (30.5)*

81 (36.2)

64 (38.6)

15 (14.6)*

 

25 to 50%

359 (27.7)

127 (27.9)

60 (26.8)

47 (28.3)

20 (19.4)

 

51 to 75%

277 (21.4)*

114 (25.1)

45 (20.1)

39 (23.5)

39 (37.9)*

 

>75%

151 (11.6)

75 (16.5)

38 (17.0)

16 (9.6)

29 (28.2)*

<0.001

Unknown

0

0

0

0

0

 
  1. Missing values were excluded from the calculations of percentages. *Standardized Pearson residuals with statistically significant deviation between observed and expected values.
  2. P-values for comparison of characteristics among the five study groups were obtained by one-way analysis of variance for continuous variables and the Chi-square test for categorical variables. All tests were two-sided. Row percentages.