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Table 1 Comparison of age at diagnosis and tumor characteristics at diagnosis between screening-detected cancers (n = 1,297) and interval cancers (n = 948)

From: Tumor phenotype and breast density in distinct categories of interval cancer: results of population-based mammography screening in Spain

  Screening-detected cancers True interval cancers False negatives Minimal-sign cancers Occult tumors  
  n = 1,297 n = 455 n = 224 n = 166 n = 103 P-value
Interval cancer entities, n (%)   455 (48.0) 224 (23.6) 166 (17.5) 103 (10.9)  
Time since last screening, n (%)       
<=12 months   89 (19.6) 73 (32.7) 53 (32.1) 44 (42.7)  
>12 months   364 (80.4) 150 (67.3) 112 (67.9) 59 (57.3) <0.001
Age, y, mean (95% CI) 57.6 (57.3, 57.9) 56.4 (55.9, 57.0) 57.4 (56.6, 58.1) 56.8 (56.0, 57.6) 55.1 (54.0, 56.2) <0.001
Tumor size, mm, mean (95% CI) 15.7 (15.1, 16.3) 25.3 (23.6, 26.9) 23.9 (22.1, 25.8) 22.7 (20.5, 24.8) 19.3 (17.0, 21.6) <0.001
Focality, n (%)       
Unifocal 1030 (82.8) 341 (79.1) 171 (78.4) 118 (74.7) 83 (85.6)  
Multifocal and/or multicentric 214 (17.2) 90 (20.9) 47 (21.6) 40 (25.3) 14 (14.4) 0.041
Unknown 53 24 6 8 6  
Tumor size, n (%)       
<= 10 mm 452 (34.8)* 36 (7.9)* 18 (8.0)* 22 (13.3)* 13 (12.6)*  
11 to 20 mm 521 (40.2) 147 (32.3) 79 (35.3) 53 (31.9) 45 (43.7)  
21 to 50 mm 233 (18.0)* 171 (37.6)* 78 (34.8)* 62 (37.3)* 23 (22.3)  
>50 mm 91 (7.0)* 101 (22.2)* 49 (21.9)* 29 (17.5) 22 (21.4)* <0.001
Unknown 0 0 0 0 0  
Lymph node involvement, n (%)       
Negative 872 (70.2)* 195 (50.4)* 102 (54.5) 76 (49.7)* 54 (62.1)  
Positive 371 (29.8)* 192 (49.6)* 85 (45.5) 77 (50.3)* 33 (37.9) <0.001
Unknown 54 68 37 13 16  
Histological type, n (%)       
Ductal 1039 (80.5) 349 (77.6) 165 (74.0) 129 (77.7) 70 (68.6)  
Lobular 109 (8.4)* 54 (12.0) 36 (16.1)* 16 (9.6) 21 (20.6)*  
Other 143 (11.1) 47 (10.4) 22 (9.9) 21 (12.7) 11 (10.8) <0.001
Unknown 6 5 1 0 1  
Histological grade, n (%)       
I 390 (34.9)* 57 (14.9)* 41 (21.4) 33 (22.9) 19 (22.6)  
II 474 (42.4) 149 (39.0) 88 (45.8) 62 (43.1) 42 (50.0)  
III 241 (21.6)* 171 (44.8)* 61 (31.8) 47 (32.6) 20 (23.8)  
NA 13 (1.2) 5 (1.3) 2 (1.0) 2 (1.4) 3 (3.6) <0.001
Breast density, n (%)       
<25% 510 (39.3)* 139 (30.5)* 81 (36.2) 64 (38.6) 15 (14.6)*  
25 to 50% 359 (27.7) 127 (27.9) 60 (26.8) 47 (28.3) 20 (19.4)  
51 to 75% 277 (21.4)* 114 (25.1) 45 (20.1) 39 (23.5) 39 (37.9)*  
>75% 151 (11.6) 75 (16.5) 38 (17.0) 16 (9.6) 29 (28.2)* <0.001
Unknown 0 0 0 0 0  
  1. Missing values were excluded from the calculations of percentages. *Standardized Pearson residuals with statistically significant deviation between observed and expected values.
  2. P-values for comparison of characteristics among the five study groups were obtained by one-way analysis of variance for continuous variables and the Chi-square test for categorical variables. All tests were two-sided. Row percentages.