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Figure 1 | Breast Cancer Research

Figure 1

From: Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties

Figure 1

Global landscape of the differences in modified DNA methylation-specific digital karyotyping and digital gene expression profiles for the parental MCF-7/S0.5 and the four TAMRcell lines as visualized by Integrative Genomics Viewer. The x axis shows the locations in the whole human genome (A) and the region of FIS1 on chromosome 7 (B). The height of the bars in modified DNA methylation-specific digital karyotyping (MMSDK) for MCF-7/S0.5 (red) shows the extent of the number of tags representing the frequency of nonmethylated CpG islands at the particular locus. The MMSDK data for the four TAMR cell lines is expressed as the difference in expression between a given TAMR and the parental cell line (red/blue). The height of the bars in digital gene expression (DGE) for MCF-7/S0.5 (green) is proportional to the gene expression level. The DGE data for the four TAMR cell lines are expressed as the difference in expression between a given TAMR cell line and the parental cell line (green/blue).

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Breast Cancer Research

ISSN: 1465-542X

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