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Figure 8 | Breast Cancer Research

Figure 8

From: GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer

Figure 8

Assessing the therapeutic effect of combination therapy with Tam plus G15 in a TAM-R xenograft. Nude mice bearing TAM-R tumors were randomized on day 0 to receive ethanol alone, Tam (50 μg) alone, G15 (4 μg) alone or G15 (4 μg) in combination with Tam (50 μg) (A). Images represent the xenograft tumors in monotherapy and combination therapy groups (B). Paraffin-embedded sections from ethanol alone (a), Tam alone (b), G15 alone (c) or G15 in combination with Tam (d) were labeled for cellular apoptosis using Tunel (C). Histogram shows percentage of apoptotic tumor cells induced by monotherapy or combination therapy for xenograft experiments (D). *P<0.05 versus ethanol alone; ** P <0.05 versus Tam alone. Results are expressed as means ± SD. Tam, 4-hydroxytamoxifen; TAM-R, tamoxifen resistant.

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