Figure 2From: GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancerEffects of 17ß-estradiol (E2), GPR30 agonist G1, and Tam on proliferation of parental MCF-7 cells and tamoxifen-resistant (TAM-R) cells. (A) Cells were counted five days after treatment with the indicated concentrations of E2 and G1. (B) Cells were counted five days after treatment with different concentrations of Tam. (C) Cells were treated with 1 μM Tam in the presence of 10 nM E2 and counted after five days. Each experiment was repeated at least three times; results are expressed as means ± SD from three independent experiments. GPR30, G-protein coupled receptor; Tam, 4-hydroxytamoxifen.Back to article page