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Figure 6 | Breast Cancer Research

Figure 6

From: A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype

Figure 6

ATG4A expression regulates tumourigenicity of SUM-149 cells. (A) Tumour-free survival of NOD SCID gamma mice, following orthotopic injection of 40,000 SUM-149 cells with reduced ATG4A levels (shATG4A), increased ATG4A levels (ATG4A-OE) or control cells (CTRL). The indicated P-values were calculated using the Wilcoxon test. (B) Representative H&E staining of sections from tumours derived from SUM-149 cells with increased ATG4A expression (ATG4A-OE) or CTRL respectively. Per group, n >10 sections were analysed. Control tumours show few circumscribed necrotic areas with few signs of inflammation, whereas ATG4A-overexpressing tumours exhibit extensive diffuse and strongly inflamed necrotic areas. Arrowheads indicate necrotic areas. Inserts show enlarged necrotic example areas with different degrees of inflammation.

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