Figure 4

Identification and prognostic performance of the five-gene Integrated Cytokine Score (ICS) in the FFPE cohort. (A) Plot of the likelihood ratio P-values of the Cox proportional hazard model fit during forward stepwise selection. The smallest P-value, indicated by the arrow, is achieved when five genes (TNFRSF17, CLIC5, HLA-F, CXCL13 and XCL2) are included in the signature. (B) The shortest path linking the five selected ICS genes with connections as determined by Ingenuity Pathway Analysis software. (C) Kaplan-Meier curves of pooled cohort dichotomized at median ICS value (red: ICS > Median, green: ICS ≤ Median).