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Table 6 Top canonical pathways of 3, 4, and 10 weeks on diet and tumor sample groups

From: Pubertal high fat diet: effects on mammary cancer development

qPCR dataset Ingenuity canonical pathways B-H-adjusted P-value Ratio Molecules
3 weeks Communication between Innate and Adaptive Immune Cells 9.11E-03 2/109 CCL3L1/CCL3L3, IL4
Granulocyte Adhesion and Diapedesisa 9.33E-03a 2/175a CCL3L1/CCL3L3, CCL24
Agranulocyte Adhesion and Diapedesisa 9.33E-03a 2/186a CCL3L1/CCL3L3, CCL24
4 weeks Human Embryonic Stem Cell Pluripotency 1.44E-04 3/156 BDNF, FZD5, LEFTY2
Mouse Embryonic Stem Cell Pluripotency 4.07E-03 2/99 LIF, FZD5
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotencya 4.07E-03a 2/114a LIF, FZD5
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 1.20E-02 2/238 TNFSF11, FZD5
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritisa 1.83E-02a 2/332a TNFSF11, FZD5
10 weeks Granulocyte Adhesion and Diapedesisa 5.66E-09a 8/166a IL1A, CXCR2, CCL17, CCL20, IL1B, CCL22, CCL19, CCL1
Agranulocyte Adhesion and Diapedesisa 5.66E-09a 8/176a IL1A, CXCR2, CCL17, CCL20, IL1B, CCL22, CCL19, CCL1
Hepatic Fibrosis / Hepatic Stellate Cell Activation 1.55E-06 6/140 VEGFA, IL1A, TGFB1, TGFA, IL1B, PGF
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 3.24E-06 5/86 IL1A, IL2, TGFB1, LTA, IL1B
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritisa 3.32E-06a 7/311a VEGFA, IL1A, TGFB1, LTA, IL1B, IL7, PGF
Tumor Molecular Mechanisms of Cancer 7.10E-07 7/378 TP53, CCND2, APAF1, BMP7, BRCA1, CTNNB1, BMP10
p53 Signaling 7.10E-07 5/96 TP53, CCND2, APAF1, BRCA1, CTNNB1
Basal Cell Carcinoma Signaling 1.27E-05 4/73 TP53, BMP7, CTNNB1, BMP10
GADD45 Signaling 1.43E-05 3/22 TP53, CCND2, BRCA1
  Role of NANOG in Mammalian Embryonic Stem Cell Pluripotencya 4.54E-05a 4/114a TP53, BMP7, CTNNB1, BMP10
  1. aPathways that are common between groups, with 10 weeks on diet, and tumor groups having an increased number of pathway molecules from 3 and 4 weeks on diet. B-H, Benjamini-Hochberg.