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Table 5 Targeted qPCR analysis comparing HFD-E tumors with LFD tumors

From: Pubertal high fat diet: effects on mammary cancer development

Breast cancer genes

HFD-E versus LFD tumor

Symbol

Description

Fold change

Brca2

Breast cancer 2

1.8

Ccnd2

Cyclin D2

3.5

Igf1r

Insulin-like growth factor I receptor

3.5

Slit2

Slit homolog 2 (Drosophila)

2.9

Trp53

Transformation related protein 53

1.6

Krt18

Keratin 18

-3.8

Krt8

Keratin 8

-4.7

Cancer pathway finder genes

HFD-E versus LFD tumor

Apaf1

Apoptotic peptidase activating factor 1

1.8

Brca1

Breast cancer 1

1.8

Ctnnb1

Catenin (cadherin associated protein), beta 1

1.8

Tert

Telomerase reverse transcriptase

1.9

  1. N = 3 mice with early developing tumors while on high fat diet (HFD-E), n = 3 low fat diet (LFD) mice with tumors. P ≤0.05 for all genes listed.