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Table 2 Targeted Q-PCR analysis of mammary glands after 3, 4, or 10 weeks and mammary tumors on HFD versus LFD

From: Pubertal high fat diet: effects on mammary cancer development

Growth factor genes Fold change HFD versus LFD
Symbol Description 3 wks MG 4 wks MG 10 wks MG Tumor
Fgf18 Fibroblast growth factor 18 2.0 - - -
Il4 Interleukin 4 2.0 - - -
Bdnf Brain derived neurotrophic factor - 2.4 - -
Lefty2 Left-right determination factor 2 - -2.5 - -
Lif Leukemia inhibitory factor - 2.8 - -
RANKL Receptor activator of nuclear factor kappa-B ligand - 17 - -
Bmp2 Bone morphogenetic protein 2 - - 2.0 -
Bmp3 Bone morphogenetic protein 3 - - 2.4 -
Fgf10 Fibroblast growth factor 10 - - 2.0 -
Gdf10 Growth differentiation factor 10 - - 1.9 -
Gdf5 Growth differentiation factor 5 - - 2.2 -
Nodal Nodal - - 2.4 -
Pgf Placental growth factor - - 2.5 -
Tgfa Transforming growth factor alpha - - 1.9 -
Tgfb1 Transforming growth factor, beta 1 - - 1.9 -
Vegfa Vascular endothelial growth factor A - - 2.1 -
Il1a Interleukin 1 alpha - - 3.0 -
Il1b Interleukin 1 beta - - 2.1 -
Il2 Interleukin 2 - - 3.0 -
Il7 Interleukin 7 - - 3.4 -
Cxcl12 Chemokine (C-X-C motif) ligand 12 - - 1.8 -
Bmp7 Bone morphogenetic protein 7 - - - 3.2
Inha Inhibin alpha - - - 2.2
Ntf3 Neurotrophin 3 - - - 53.4
Bmp10 Bone morphogenetic protein 10 - - - -3.4
  1. N = 3 high fat diet (HFD) mice, n = 3 low fat diet (LFD) mice, n = 3 HFD mice with early developing tumors (HFD-E), n = 3 LFD mice with tumors. P ≤0.05 for all genes listed.