Pattern of recurrence of early breast cancer is different according to intrinsic subtype and proliferation index

Breast Cancer Research

Table 9 Intrinsic subtype recurrence hazard rates over time and hazard ratios (six-marker definition) ^a

Years after surgery	Luminal A hazard rate^b	HR	Luminal B hazard rate	HR	Luminal HER2 hazard rate	HR	HER2-enriched hazard rate	HR	Basal-like hazard rate	HR	TNP nonbasal hazard rate	HR
2	0.24 (0.2 to 0.3)	1	0.50 (0.4 to 0.6)	2.05	0.56 (0.3 to 0.9)	2.30	1.83 (1.1 to 3.1)	7.53	0.84 (0.6 to 1.2)	3.46	0.60 (0.3 to 1.1)	2.46
3	0.32 (0.2 to 0.4)	1	0.54 (0.4 to 0.6)	1.68	0.46 (0.2 to 0.8)	1.43	0.45 (0.1 to 1.4)	1.41	0.58 (0.4 to 0.8)	1.83	0.66 (0.4 to 1.1)	2.06
4	0.33 (0.2 to 0.4)	1	0.43 (0.3 to 0.5)	1.32	0.27 (0.1 to 0.5)	0.82	0.41 (0.1 to 1.6)	1.27	0.29 (0.2 to 0.5)	0.90	0.60 (0.3 to 1.1)	1.84
5	0.29 (0.2 to 0.3)	1	0.29 (0.2 to 0.4)	1.00	0.20 (0.07 to 0.5)	0.68	0.32 (0.06 to 1.6)	1.09	0.14 (0.05 to 0.3)	0.47	0.51 (0.3 to 1.0)	1.75
6	0.26 (0.1 to 0.3)	1	0.26 (0.1 to 0.4)	1.02	0.19 (0.05 to 0.6)	0.72	0.55 (0.1 to 2.2)	2.12	0.08 (0.03 to 0.2)	0.29	0.39 (0.2 to 0.9)	1.51
7	0.21 (0.1 to 0.3)	1	0.31 (0.2 to 0.5)	1.43	0.13 (0.03 to 0.5)	0.59	NA	NA	0.05 (0.01 to 0.3)	0.24	0.25 (0.08 to 0.8)	1.16
8	0.18 (0.1 to 0.2)	1	0.35 (0.2 to 0.6)	1.95	0.01 (0.00 to 0.04)	0.06	NA	NA	0.09 (0.02 to 0.3)	0.49	0.15 (0.04 to 0.6)	0.86
9	0.16 (0.1 to 0.3)	1	0.38 (0.2 to 0.7)	2.33	NA	NA	NA	NA	0.14 (0.04 to 0.4)	0.84	0.05 (0.01 to 0.2)	0.30
10	0.21 (0.1 to 0.3)	1	0.28 (0.1 to 0.6)	1.33	NA	NA	NA	NA	0.21 (0.08 to 0.6)	1.00	NA	NA

^aHER2, human epidermal growth factor receptor 2; HR, hazard ratio; NA, not available; TNP, triple-negative phenotype. ^bReference value. Note: 95% confidence interval is represented between the parentheses.

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